{"doi":"10.1159/000468765","title":"Translation of Poliovirus mRNA","abstract":"<jats:p>Ribosome binding to cellular eukaryotic mRNAs is proposed to occur by initial\nattachment at or near the mRNA 5' cap structure (m^7 GpppN, where N is any nucleotide)\nfollowed by scanning till the appropriate initiator AUG is encountered. A pivotal aspect of\nthis model is the obligatory entry of the ribosomes at the 5' end of the mRNA (regardless if it\ncontains a cap structure). Recent experiments, however, demonstrated that ribosomes can\naccess certain mRNAs by internal binding to the 5'-untranslated region. This was most\nclearly demonstrated for members of the picornavirus family such as poliovirus and encephalomyocarditis\nvirus. Further experiments suggest that other viral mRNAs and even cellular\nmRNAs may use similar mechanisms of ribosome binding. Here we describe some\nfeatures of the poliovirus 5'-untranslated region and possible trans-acting factors that are\ninvolved in this mechanism of translation.</jats:p>","journal":"Enzyme","year":2017,"id":22323,"datarank":1.8042216152631432,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":1.2891235345903713,"self_endowment_contribution":0.515098080672772,"citer_contribution":1.2891235345903713,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":29,"citers_with_citation_signal":28,"citers_with_endowment":28,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":140715,"name":"Karen Meerovitch","orcid":null,"position":1,"is_corresponding":false},{"id":17875,"name":"Nahum Sonenberg","orcid":"0000-0002-4707-8759","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1966842","pmcid":null,"openalex_id":"https://openalex.org/W2419044071","authors":[],"funders":[],"total_grants":0,"fwci":1.2702,"citation_percentile":0.81210134,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2017,"count":1},{"year":2018,"count":6},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://karger.com/article-pdf/doi/10.1159/000468765","host_type":"publisher"},{"url":"https://doi.org/10.1159/000468765","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1966842","host_type":"repository"}],"fields_of_study":["Viral Infections and Immunology Research","RNA Research and Splicing","RNA and protein synthesis mechanisms","Biology","Medicine","Animals","Codon","Humans","Nucleic Acid Conformation","Organ Specificity","Peptide Chain Initiation, Translational","Poliovirus","Protein Biosynthesis","RNA Caps","RNA, Messenger","RNA, Viral","Regulatory Sequences, Nucleic Acid","Ribosomes"],"mesh_terms":["Animals","Codon","Humans","Nucleic Acid Conformation","Organ Specificity","Peptide Chain Initiation, Translational","Regulatory Sequences, Nucleic Acid","Ribosomes","RNA Caps","RNA, Messenger","RNA, Viral","Protein Biosynthesis","Poliovirus"],"keywords":["Picornavirus","Internal ribosome entry site","Translation (biology)","Poliovirus","Messenger RNA","Ribosome","Untranslated region","Ribosomal binding site","Five prime untranslated region","Cell biology","Biology","Initiation factor","Eukaryotic translation","EIF4E","Three prime untranslated region","Shine-Dalgarno sequence","RNA","Virology","Virus","Genetics","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T19:12:18.807182Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}