{"doi":"10.1159/000455848","title":"Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells","abstract":"<b><i>Objective:</i></b> To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. <b><i>Setting:</i></b> In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations. <b><i>Result:</i></b> A significantly increased number of CLs was found in the decidua treated with mifepristone. <b><i>Conclusion:</i></b> Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination.","journal":"Gynecologic and Obstetric Investigation","year":2017,"id":616930,"datarank":0.43052294631641774,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.13863642395812073,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.13863642395812073,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":5,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281248,"name":"Feng Zhou","orcid":"0000-0002-7626-4139","position":1,"is_corresponding":false},{"id":1484075,"name":"Jiale Qin","orcid":"0000-0003-4769-4348","position":2,"is_corresponding":false},{"id":1590751,"name":"Zhida Qian","orcid":null,"position":3,"is_corresponding":false},{"id":481638,"name":"Lili Huang","orcid":"0000-0002-7085-7646","position":4,"is_corresponding":false},{"id":1590750,"name":"Linxiang Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells","abstract":"<b><i>Objective:</i></b> To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. <b><i>Setting:</i></b> In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations. <b><i>Result:</i></b> A significantly increased number of CLs was found in the decidua treated with mifepristone. <b><i>Conclusion:</i></b> Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29080885","pmcid":null,"openalex_id":"https://openalex.org/W2765600151","authors":[],"funders":[],"total_grants":0,"fwci":0.2207,"citation_percentile":0.54152244,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/455848","host_type":"publisher"},{"url":"https://doi.org/10.1159/000455848","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29080885","host_type":"repository"}],"fields_of_study":["Reproductive System and Pregnancy","Preterm Birth and Chorioamnionitis","Reproductive Health and Contraception"],"mesh_terms":["Abortifacient Agents, Steroidal","Abortion, Induced","Decidua","Female","Humans","Killer Cells, Natural","Pregnancy","Mifepristone","T-Lymphocytes, Regulatory"],"keywords":["Decidua","Cytotoxic T cell","Mifepristone","Granzyme B","Granzyme A","CLs upper limits","CD8","Granzyme","Medicine","Perforin","Biology","Immunology","Internal medicine","Endocrinology","Immune system","Pregnancy","In vitro","Fetus","Placenta","Cytotoxic T cells","Regulatory T cells","Cytotoxic lymphocytes","Cd56+ Natural Killer Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T00:23:45.458180Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}