{"doi":"10.1159/000442424","title":"Resting-State Blood Oxygen Level-Dependent Functional MRI: A Paradigm Shift in Preoperative Brain Mapping","abstract":"<jats:p>Currently, functional magnetic resonance imaging (fMRI) facilitates a preoperative awareness of an association of an eloquent region with a tumor. This information gives the neurosurgeon helpful information that can aid in creating a surgical strategy. Typically, task-based fMRI has been employed to preoperatively localize speech and motor function. Task-based fMRI depends on the patient's ability to comply with the task paradigm, which often is impaired in the setting of a brain tumor. This problem is overcome by using resting-state fMRI (rs-fMRI) to localize function. rs-fMRI measures spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, representing the brain's functional organization. In a neurosurgical context, it allows noninvasive simultaneous assessment of multiple large-scale distributed networks. Compared with task-related fMRI, rs-fMRI provides more comprehensive information on the functional architecture of the brain and is applicable in settings where task-related fMRI may provide inadequate information or could not be performed. Taken together, rs-fMRI substantially expands the preoperative mapping capability in efficiency, effectiveness, and scope. In this article, a brief introduction into rs-fMRI processing methods is followed by a detailed discussion on the role rs-fMRI plays in presurgical planning.</jats:p>","journal":"Stereotactic and Functional Neurosurgery","year":2015,"id":40575,"datarank":1.2786015049968766,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.7541253707769046,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.7541253707769046,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":27,"citers_with_citation_signal":23,"citers_with_endowment":23,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196932,"name":"Monica Allen","orcid":null,"position":1,"is_corresponding":false},{"id":196933,"name":"Mudassar Kamran","orcid":null,"position":2,"is_corresponding":false},{"id":196934,"name":"Ammar H. 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Leuthardt","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26784290","pmcid":null,"openalex_id":"https://openalex.org/W2290422761","authors":[],"funders":[],"total_grants":0,"fwci":1.3321,"citation_percentile":0.80365555,"influential_citations":0,"citation_trend":[{"year":2017,"count":6},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/442424","host_type":"journal"},{"url":"https://www.karger.com/Article/Pdf/442424","host_type":"BRONZE"},{"url":"https://www.karger.com/Article/Pdf/442424","host_type":"publisher"},{"url":"https://karger.com/sfn/article-pdf/93/6/427/3926271/000442424.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1159/000442424","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26784290","host_type":"repository"}],"fields_of_study":["Functional Brain Connectivity Studies","Advanced MRI Techniques and Applications","Neural dynamics and brain function","Psychology","Medicine","Engineering","Brain Mapping","Humans","Magnetic Resonance Imaging","Preoperative Care"],"mesh_terms":["Brain Mapping","Humans","Magnetic Resonance Imaging","Preoperative Care"],"keywords":["Functional magnetic resonance imaging","Blood-oxygen-level dependent","Resting state fMRI","Context (archaeology)","Task (project management)","Brain mapping","Brain activity and meditation","Neuroscience","Magnetic resonance imaging","Medicine","Computer science","Psychology","Electroencephalography","Radiology"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.19159210.v1","title":"Additional file 1 of Cerebral mechanism of opposing needling for managing acute pain after unilateral total knee arthroplasty: study protocol for a randomized, sham-controlled clinical trial","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19159210","title":"Additional file 1 of Cerebral mechanism of opposing needling for managing acute pain after unilateral total knee arthroplasty: study protocol for a randomized, sham-controlled clinical trial","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T07:36:27.860149Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}