{"doi":"10.1159/000324115","title":"Frequent Occurrence of the Triphasic Response (Diabetes Insipidus/Hyponatremia/Diabetes Insipidus) after Surgery for Craniopharyngioma in Childhood","abstract":"<jats:p>&lt;i&gt;Background/Aims:&lt;/i&gt; It is not exactly known how many children develop the triphasic response (diabetes insipidus (DI)/hyponatremia/DI) immediately after surgery for childhood craniopharyngioma; neither is it known which factors predict this. We studied the occurrence of the triphasic response after primary surgery for craniopharyngioma in children, and aimed to identify possible predictors. &lt;i&gt;Methods:&lt;/i&gt; Patients &lt;18 years old who had undergone a primary craniopharyngioma resection between January 1990 and February 2010 in either of the 2 academic centers in Amsterdam were studied retrospectively. &lt;i&gt;Results:&lt;/i&gt; Twenty-one patients (5 males) fulfilled the inclusion criteria. Median age at surgery was 9.1 (range: 4.0–15.1) years. Six patients developed a triphasic response (29%). Of all factors, only the duration of surgery was found to be a predictor of a triphasic response: 8.5 (6.0–11.0) versus 4.6 (3.5–11.5) h in patients who did not develop a triphasic response (p = 0.03). &lt;i&gt;Conclusion:&lt;/i&gt; After primary surgery for a craniopharyngioma, a considerable number of patients develop a triphasic response in the regulation of the sodium and water balance. This is predicted by (factors associated with) a longer duration of surgery. Other predictors could not be identified, which may be due to the small sample size.</jats:p>","journal":"Hormone Research in Paediatrics","year":2011,"id":41765,"datarank":2.4379430899474315,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":1.8604209496909228,"self_endowment_contribution":0.5775221402565088,"citer_contribution":1.8604209496909228,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":45,"citers_with_citation_signal":35,"citers_with_endowment":35,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200763,"name":"Nitash Zwaveling-Soonawala","orcid":null,"position":1,"is_corresponding":false},{"id":200764,"name":"Marie J.E. Walenkamp","orcid":null,"position":2,"is_corresponding":false},{"id":200765,"name":"Thomas Vulsma","orcid":null,"position":3,"is_corresponding":false},{"id":200766,"name":"A.S. Paul van Trotsenburg","orcid":null,"position":4,"is_corresponding":false},{"id":200767,"name":"Joost Rotteveel","orcid":null,"position":5,"is_corresponding":false},{"id":200762,"name":"Martijn J.J. Finken","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21701131","pmcid":null,"openalex_id":"https://openalex.org/W2123050083","authors":[],"funders":[],"total_grants":0,"fwci":1.5148,"citation_percentile":0.82374039,"influential_citations":2,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":5},{"year":2020,"count":1},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/324115","host_type":"publisher"},{"url":"https://doi.org/10.1159/000324115","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21701131","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/3d1acad8-994f-48dc-bdb1-5ba8f4ef5385","host_type":"repository"},{"url":"https://research.vumc.nl/en/publications/101fdcb7-70e4-401f-9a6b-fdc66e6d6724","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/frequent-occurrence-of-the-triphasic-response-diabetes-insipidushyponatremiadiabetes-insipidus-after-surgery-for-craniopharyngioma-in-childhood(d63d3d9a-5bab-4aba-bbf4-409143afe4c7).html","host_type":"repository"},{"url":"https://research.vu.nl/en/publications/5b70b1cc-dbe5-4354-8f88-37db5adb8a00","host_type":"repository"}],"fields_of_study":["Pituitary Gland Disorders and Treatments","Electrolyte and hormonal disorders","Glycogen Storage Diseases and Myoclonus","Medicine","Adolescent","Child","Child, Preschool","Craniopharyngioma","Diabetes Insipidus","Female","Humans","Hyponatremia","Male","Netherlands","Neurosurgical Procedures","Pituitary Neoplasms","Postoperative Complications","Prevalence","Retrospective Studies","Time Factors"],"mesh_terms":["Adolescent","Child","Child, Preschool","Craniopharyngioma","Diabetes Insipidus","Female","Humans","Hyponatremia","Male","Netherlands","Pituitary Neoplasms","Postoperative Complications","Retrospective Studies","Time Factors","Prevalence","Neurosurgical Procedures"],"keywords":["Craniopharyngioma","Diabetes insipidus","Medicine","Hyponatremia","Diabetes mellitus","Pediatrics","Surgery","Internal medicine","Endocrinology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-13T06:09:38.999157Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}