{"doi":"10.1159/000321354","title":"Microvascular Determinants of Cognitive Decline and Brain Volume Change in Elderly Patients with Type 2 Diabetes","abstract":"<jats:p>&lt;i&gt;Background/Aims:&lt;/i&gt; The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM). &lt;i&gt;Methods:&lt;/i&gt; Sixty-eight elderly patients with T2DM had 2 cognitive assessments with a 4-year interval. Two MRI scans, performed at the same time as the cognitive assessments, were available from 55 patients. Changes in cognitive performance over time were expressed as a regression-based index (RBI). Automated volumetric measurements of total brain, lateral ventricles and white matter hyperintensities were performed. The relationship between baseline microvascular complications [diabetic retinopathy, peripheral neuropathy or albuminuria (micro- or macroalbuminuria)] and cognition and brain volumes was examined with linear regression analyses adjusted for age and sex (for cognition also for IQ). &lt;i&gt;Results:&lt;/i&gt; At baseline, diabetic retinopathy was present in 18% of patients, peripheral neuropathy in 36%, albuminuria in 15%. Retinopathy or neuropathy were not significantly associated with baseline cognition or brain volumes, or changes in these measures over time. Albuminuria was associated with a lower composite RBI score, indicating accelerated cognitive decline (adjusted mean difference between patients with or without albuminuria: –0.58, 95% CI –0.85 to –0.31, p &lt; 0.001). &lt;i&gt;Conclusion: &lt;/i&gt;Albuminuria predicted accelerated cognitive decline in patients with T2DM, but other microvascular complications were unrelated to accelerated cognitive decline or brain MRI abnormalities.</jats:p>","journal":"Dementia and Geriatric Cognitive Disorders","year":2010,"id":673080,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":176873,"name":"Yael D. Reijmer","orcid":null,"position":1,"is_corresponding":false},{"id":630635,"name":"Esther van den Berg","orcid":"0000-0002-8120-7366","position":2,"is_corresponding":false},{"id":1758585,"name":"Marja A. Breedijk","orcid":null,"position":3,"is_corresponding":false},{"id":72452,"name":"L. Jaap Kappelle","orcid":"0000-0001-8665-6630","position":4,"is_corresponding":false},{"id":1758586,"name":"Max A. Viergever","orcid":null,"position":5,"is_corresponding":false},{"id":176880,"name":"Geert Jan Biessels","orcid":null,"position":6,"is_corresponding":false},{"id":1044131,"name":"Jeroen de Bresser","orcid":"0000-0003-0759-8407","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microvascular Determinants of Cognitive Decline and Brain Volume Change in Elderly Patients with Type 2 Diabetes","abstract":"<jats:p>&lt;i&gt;Background/Aims:&lt;/i&gt; The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM). &lt;i&gt;Methods:&lt;/i&gt; Sixty-eight elderly patients with T2DM had 2 cognitive assessments with a 4-year interval. Two MRI scans, performed at the same time as the cognitive assessments, were available from 55 patients. Changes in cognitive performance over time were expressed as a regression-based index (RBI). Automated volumetric measurements of total brain, lateral ventricles and white matter hyperintensities were performed. The relationship between baseline microvascular complications [diabetic retinopathy, peripheral neuropathy or albuminuria (micro- or macroalbuminuria)] and cognition and brain volumes was examined with linear regression analyses adjusted for age and sex (for cognition also for IQ). &lt;i&gt;Results:&lt;/i&gt; At baseline, diabetic retinopathy was present in 18% of patients, peripheral neuropathy in 36%, albuminuria in 15%. Retinopathy or neuropathy were not significantly associated with baseline cognition or brain volumes, or changes in these measures over time. Albuminuria was associated with a lower composite RBI score, indicating accelerated cognitive decline (adjusted mean difference between patients with or without albuminuria: –0.58, 95% CI –0.85 to –0.31, p &lt; 0.001). &lt;i&gt;Conclusion: &lt;/i&gt;Albuminuria predicted accelerated cognitive decline in patients with T2DM, but other microvascular complications were unrelated to accelerated cognitive decline or brain MRI abnormalities.</jats:p>","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20962529","pmcid":null,"openalex_id":"https://openalex.org/W2079222945","authors":[],"funders":[],"total_grants":0,"fwci":2.3359,"citation_percentile":0.87569136,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":7},{"year":2014,"count":10},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":6},{"year":2018,"count":9},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/321354","host_type":"publisher"},{"url":"https://doi.org/10.1159/000321354","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20962529","host_type":"repository"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Retinal Imaging and Analysis","Neurological and metabolic disorders","Aged","Aged, 80 and over","Albuminuria","Atrophy","Brain","Capillaries","Cerebral Infarction","Cognition Disorders","Diabetes Mellitus, Type 2","Diabetic Neuropathies","Diabetic Retinopathy","Disease Progression","Female","Humans","Image Processing, Computer-Assisted","Longitudinal Studies","Magnetic Resonance Imaging","Male","Middle Aged","Neuropsychological Tests"],"mesh_terms":["Aged","Aged, 80 and over","Albuminuria","Atrophy","Brain","Capillaries","Cerebral Infarction","Cognition Disorders","Diabetes Mellitus, Type 2","Diabetic Neuropathies","Diabetic Retinopathy","Female","Humans","Image Processing, Computer-Assisted","Longitudinal Studies","Magnetic Resonance Imaging","Male","Middle Aged","Neuropsychological Tests","Disease Progression"],"keywords":["Albuminuria","Cognitive decline","Hyperintensity","Medicine","Internal medicine","Brain size","Cardiology","Diabetes mellitus","Cognition","Retinopathy","Cognitive disorder","Effects of sleep deprivation on cognitive performance","Diabetic retinopathy","Magnetic resonance imaging","Endocrinology","Dementia","Psychiatry","Radiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12992071.v1","title":"Additional file 1 of The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12992071","title":"Additional file 1 of The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T12:17:08.914829Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}