{"doi":"10.1159/000319632","title":"Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China","abstract":"<jats:p>&lt;i&gt;Objectives:&lt;/i&gt; To characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Northern China, and to explore the relationship between the EBV genotypes and NPC. &lt;i&gt;Methods:&lt;/i&gt; The genotypes of EBV strains were analyzed by the polymerase chain reaction and restriction fragment length polymorphism. &lt;i&gt;Results:&lt;/i&gt; The predominant EBV type was A, C or F in both NPC and healthy individuals. The distributions of the EBV subtypes between NPC and healthy donors were not significantly different (p &gt; 0.05). The frequency of type f strains in NPC was significantly lower in Northern China than in Southern China. &lt;i&gt;Conclusions:&lt;/i&gt; No evidence of special EBV genotypes associated with NPC was found, suggesting that EBV strains derived from the NPC patients may reflect geographic distribution rather than being NPC restricted.</jats:p>","journal":"Intervirology","year":2011,"id":610302,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":406772,"name":"Yun Wang","orcid":"0000-0001-7983-5905","position":1,"is_corresponding":false},{"id":30776,"name":"Xia Liu","orcid":"0000-0002-9209-0562","position":2,"is_corresponding":false},{"id":1569099,"name":"Yan Chao","orcid":null,"position":3,"is_corresponding":false},{"id":1128955,"name":"Xiaoming Xing","orcid":null,"position":4,"is_corresponding":false},{"id":1217400,"name":"Chengquan Zhao","orcid":"0000-0001-7524-3048","position":5,"is_corresponding":false},{"id":1275880,"name":"Chengyu Liu","orcid":"0000-0001-9081-0805","position":6,"is_corresponding":false},{"id":1569100,"name":"Bing Luo","orcid":null,"position":7,"is_corresponding":false},{"id":1320252,"name":"Ying Cui","orcid":"0000-0001-9201-0465","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China","abstract":"<jats:p>&lt;i&gt;Objectives:&lt;/i&gt; To characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Northern China, and to explore the relationship between the EBV genotypes and NPC. &lt;i&gt;Methods:&lt;/i&gt; The genotypes of EBV strains were analyzed by the polymerase chain reaction and restriction fragment length polymorphism. &lt;i&gt;Results:&lt;/i&gt; The predominant EBV type was A, C or F in both NPC and healthy individuals. The distributions of the EBV subtypes between NPC and healthy donors were not significantly different (p &gt; 0.05). The frequency of type f strains in NPC was significantly lower in Northern China than in Southern China. &lt;i&gt;Conclusions:&lt;/i&gt; No evidence of special EBV genotypes associated with NPC was found, suggesting that EBV strains derived from the NPC patients may reflect geographic distribution rather than being NPC restricted.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20948223","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/319632","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Herpesvirus 4, Human","Carcinoma","Nasopharyngeal Neoplasms","Cluster Analysis","Polymerase Chain Reaction","Genotype","Polymorphism, Genetic","Polymorphism, Restriction Fragment Length","Adult","China","Molecular Epidemiology","Molecular Typing","Nasopharyngeal Carcinoma"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T21:11:45.738919Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}