{"doi":"10.1159/000236402","title":"Complement Activation and C3 Allotype Distribution in Patients with Bronchial Asthma","abstract":"<jats:p>61 patients suffering from intrinsic (idiotypic) or extrinsic (allergic) asthma were investigated for signs of complement activation and for C3 phenotype distribution. Activation of both the classical and alternative pathway of the complement system and generation of the membrane attack complex could be assessed by ELISAs for the activation-specific protein-protein complexes C1rsC1 inhibitor, C3b(Bb)P and SC5b-9, respectively. A possible deficiency of the complement regulatory proteins C1 inhibitor, factor H and factor I was excluded. In contrast to earlier studies, C3 allele frequencies did not differ from those found in the healthy population. Our results support the role of complement activation during bronchial asthma and, thereby, provide further evidence for the inflammatory nature of the disease.</jats:p>","journal":"International Archives of Allergy and Immunology","year":2009,"id":629986,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1631869,"name":"Fabio Fernandes Morato Castro","orcid":null,"position":1,"is_corresponding":false},{"id":1631870,"name":"Ursula Rother","orcid":null,"position":2,"is_corresponding":false},{"id":1631871,"name":"John Alexander Nakhosteen","orcid":null,"position":3,"is_corresponding":false},{"id":1631872,"name":"Reinhold Deppisch","orcid":null,"position":4,"is_corresponding":false},{"id":1631873,"name":"Michael Schmitz-Schumann","orcid":null,"position":5,"is_corresponding":false},{"id":1631868,"name":"Michael Kirschfink","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Complement Activation and C3 Allotype Distribution in Patients with Bronchial Asthma","abstract":"<jats:p>61 patients suffering from intrinsic (idiotypic) or extrinsic (allergic) asthma were investigated for signs of complement activation and for C3 phenotype distribution. Activation of both the classical and alternative pathway of the complement system and generation of the membrane attack complex could be assessed by ELISAs for the activation-specific protein-protein complexes C1rsC1 inhibitor, C3b(Bb)P and SC5b-9, respectively. A possible deficiency of the complement regulatory proteins C1 inhibitor, factor H and factor I was excluded. In contrast to earlier studies, C3 allele frequencies did not differ from those found in the healthy population. Our results support the role of complement activation during bronchial asthma and, thereby, provide further evidence for the inflammatory nature of the disease.</jats:p>","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8443468","pmcid":null,"openalex_id":"https://openalex.org/W2026099298","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.13304553,"influential_citations":0,"citation_trend":[{"year":2024,"count":2}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/236402","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000236402","host_type":"publisher"},{"url":"https://doi.org/10.1159/000236402","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8443468","host_type":"repository"}],"fields_of_study":["Complement system in diseases","Coagulation, Bradykinin, Polyphosphates, and Angioedema","Blood Coagulation and Thrombosis Mechanisms","Alleles","Asthma","Complement Activation","Complement C3","Female","Humans","Male","Polymorphism, Genetic"],"mesh_terms":["Alleles","Asthma","Complement Activation","Complement C3","Female","Humans","Male","Polymorphism, Genetic"],"keywords":["Complement system","Immunology","Alternative complement pathway","Allotype","Asthma","Complement membrane attack complex","Decay-accelerating factor","Population","Complement factor B","Complement (music)","Classical complement pathway","Complement component 5","Medicine","Antibody","Phenotype","Biology","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T20:12:08.771518Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}