{"doi":"10.1159/000234504","title":"Decreased T Helper Cell Function in Patients with Cystic Fibrosis","abstract":"<jats:p>T cell immune function was further evaluated in cystic fibrosis (CF) patients. CF patients, regardless of severity of pulmonary disease or colonization with Pseudomonas aeruginosa, had lower percentages of T helper cells (p &lt; 0.01) and decreased T helper function as demonstrated by diminished T help for control B cell pokeweed mitogen-stimulated IgG (p &lt; 0.01) and IgM (p &lt; 0.01) synthesis. Increased T suppressor function, measured by co-culture with control B and T cells, was noted in only 25% of CF patients. CF patients’ T cells exhibited decreased allogeneic T cell cytotoxicity compared to normal controls (p &lt; 0.01). This study extends previous studies demonstrating decreased T cell functions in CF patients and indicates a specific decrease in T helper function.</jats:p>","journal":"International Archives of Allergy and Applied Immunology","year":2009,"id":684484,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1788217,"name":"Raymond G. 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CF patients, regardless of severity of pulmonary disease or colonization with Pseudomonas aeruginosa, had lower percentages of T helper cells (p &lt; 0.01) and decreased T helper function as demonstrated by diminished T help for control B cell pokeweed mitogen-stimulated IgG (p &lt; 0.01) and IgM (p &lt; 0.01) synthesis. Increased T suppressor function, measured by co-culture with control B and T cells, was noted in only 25% of CF patients. CF patients’ T cells exhibited decreased allogeneic T cell cytotoxicity compared to normal controls (p &lt; 0.01). This study extends previous studies demonstrating decreased T cell functions in CF patients and indicates a specific decrease in T helper function.</jats:p>","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2962950","pmcid":null,"openalex_id":"https://openalex.org/W2005449092","authors":[],"funders":[],"total_grants":0,"fwci":0.2263,"citation_percentile":0.56195023,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2017,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/234504","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000234504","host_type":"publisher"},{"url":"https://doi.org/10.1159/000234504","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2962950","host_type":"repository"}],"fields_of_study":["Immunodeficiency and Autoimmune Disorders","Adolescent","Adult","Child","Cystic Fibrosis","Cytotoxicity, Immunologic","Female","Humans","Immunoglobulin G","Male","Phenotype","T-Lymphocytes, Helper-Inducer","T-Lymphocytes, Regulatory"],"mesh_terms":["Adolescent","Adult","Child","Cystic Fibrosis","Cytotoxicity, Immunologic","Female","T-Lymphocytes, Helper-Inducer","Humans","Immunoglobulin G","Male","Phenotype","T-Lymphocytes, Regulatory"],"keywords":["Cystic fibrosis","Immunology","Medicine","Fibrosis","Pathology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T14:14:08.433466Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}