{"doi":"10.1159/000217283","title":"Consequences Of Transcellular Biosynthesis Of Leukotriene C4 On Organ Function","abstract":"<jats:p>Formation of eicosanoids is a special mode of cell communication whereby production of eicosanoids by mixed cell populations differs from that expected from each individual cell. Transcellular biosynthesis of leukotriene C&lt;sub&gt;4&lt;/sub&gt; occurs via transfer of the reactive intermediate leukotriene A4 from neutrophils to vicinal acceptor cells devoid of 5-lipoxygenase activity such as platelets or vascular cells. Evidence for the in vivo relevance of transcellular eicosanoid metabolism results from experiments using the isolated beating rabbit heart perfused with activated neutrophils. The resultant leukotriene C&lt;sub&gt;4&lt;/sub&gt; synthesis is timely related to the pressor response of the coronary arteries and inflammatory damage of the heart by edema formation and neutrophil infiltration into the organ. Blockade of leukotriene C&lt;sub&gt;4&lt;/sub&gt; synthesis by 5-lipoxygenase inhibitors or leukotriene C&lt;sub&gt;4&lt;/sub&gt; actions by respective receptor antagonists facilitated significant protective effects. Further confirmation of the potential role of LTC&lt;sub&gt;4&lt;/sub&gt; in myocardial ischemia comes from in vivo studies in the rabbit.</jats:p>","journal":"Haemostasis","year":2009,"id":30535,"datarank":0.7296351868314749,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.3448927832122443,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.3448927832122443,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":10,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":165698,"name":"Angelo Sala","orcid":null,"position":1,"is_corresponding":false},{"id":165699,"name":"Giuseppe Rossoni","orcid":null,"position":2,"is_corresponding":false},{"id":165700,"name":"Ferruccio Berti","orcid":null,"position":3,"is_corresponding":false},{"id":165701,"name":"Reiner Muller-Peddinghaus","orcid":null,"position":4,"is_corresponding":false},{"id":165702,"name":"Giancarlo Folco","orcid":null,"position":5,"is_corresponding":false},{"id":163011,"name":"Jacques Maclouf","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8979109","pmcid":null,"openalex_id":"https://openalex.org/W1964652027","authors":[],"funders":[],"total_grants":0,"fwci":0.5354,"citation_percentile":0.67360267,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2017,"count":1},{"year":2019,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/217283","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000217283","host_type":"publisher"},{"url":"https://doi.org/10.1159/000217283","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8979109","host_type":"repository"}],"fields_of_study":["Asthma and respiratory diseases","Biology","Medicine","Animals","Arachidonate 5-Lipoxygenase","Blood Platelets","Blood Pressure","Brain Ischemia","Cardiovascular Diseases","Cell Communication","Eicosanoids","Endothelium, Vascular","Humans","Leukotriene A4","Leukotriene C4","Muscle, Smooth, Vascular","Myocardial Ischemia","Neutrophils","Rabbits"],"mesh_terms":["Animals","Arachidonate 5-Lipoxygenase","Blood Platelets","Blood Pressure","Cardiovascular Diseases","Cell Communication","Brain Ischemia","Endothelium, Vascular","Humans","Muscle, Smooth, Vascular","Neutrophils","Rabbits","Eicosanoids","Myocardial Ischemia","Leukotriene A4","Leukotriene C4"],"keywords":["Transcellular","Leukotriene","Eicosanoid","Leukotriene B4","Leukotriene C4","Chemistry","Thromboxane","Prostacyclin","In vivo","Internal medicine","Thromboxane A2","Arachidonate 5-lipoxygenase","Hydroxyeicosatetraenoic acid","Eicosanoid metabolism","Endocrinology","Leukotriene D4","Platelet","Receptor","Lipoxygenase","Inflammation","Biology","Biochemistry","Arachidonic acid","Medicine","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T03:22:00.774105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}