{"doi":"10.1159/000194748","title":"Pulmonary Hypertension Induced in Rats by Monocrotaline and Chronic Hypoxia is Reduced by p-Chlorophenylalanine","abstract":"<jats:p>We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p-chlorophenylalanine (PCPA) which inhibits 5-HT synthesis. We measured right ventricular mean systolic pressure (Prvs), right ventricular hypertrophy, medial thickness of muscular pulmonary arteries, and muscularization of pulmonary arterioles 17 days after a single dose of monocrotaline (60 mg/kg) and after 26 days of chronic hypobaric hypoxia (380 mm Hg). In monocrotaline pulmonary hypertension, pretreatment with PCPA (500 mg/kg) was associated with significant reductions (p &lt; 0.05) in Prvs (29%), right ventricular hypertrophy (33%), and medial thickness of muscular pulmonary arteries (14%). In chronic hypoxic pulmonary hypertension, pretreatment with PCPA was associated with significant reductions in Prvs (20%), right ventricular hypertrophy (28%), medial thickness of muscular pulmonary arteries (14%), and muscularization of pulmonary arterioles (47%). 5-HT may play a role in the development of monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats.</jats:p>","journal":"Respiration","year":2009,"id":26651,"datarank":1.677605376159345,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":1.2072812437699725,"self_endowment_contribution":0.47032413238937254,"citer_contribution":1.2072812437699725,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":19,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":153701,"name":"P.M. Keane","orcid":null,"position":1,"is_corresponding":false},{"id":153702,"name":"K.L. Suyama","orcid":null,"position":2,"is_corresponding":false},{"id":153700,"name":"J.M. Kay","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3156395","pmcid":null,"openalex_id":"https://openalex.org/W2089725583","authors":[],"funders":[],"total_grants":0,"fwci":0.7441,"citation_percentile":0.76712009,"influential_citations":1,"citation_trend":[{"year":2012,"count":2},{"year":2020,"count":2}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/194748","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000194748","host_type":"publisher"},{"url":"https://doi.org/10.1159/000194748","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3156395","host_type":"repository"}],"fields_of_study":["Pulmonary Hypertension Research and Treatments","Chronic Obstructive Pulmonary Disease (COPD) Research","Neuroscience of respiration and sleep","Medicine","Environmental Science","Animals","Chronic Disease","Female","Fenclonine","Hypertension, Pulmonary","Hypoxia","Monocrotaline","Pyrrolizidine Alkaloids","Rats","Rats, Inbred Strains","Serotonin"],"mesh_terms":["Animals","Hypoxia","Chronic Disease","Female","Hypertension, Pulmonary","Fenclonine","Pyrrolizidine Alkaloids","Rats, Inbred Strains","Serotonin","Monocrotaline","Rats"],"keywords":["Right ventricular hypertrophy","Pulmonary hypertension","Medicine","Internal medicine","Hypoxia (environmental)","Cardiology","Muscle hypertrophy","Ventricular pressure","Pulmonary artery","Cardiac hypertrophy","Blood pressure","Anesthesia","Oxygen"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T15:08:34.606581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}