{"doi":"10.1159/000180299","title":"Effects of Castration on Androstenedione, Testosterone and Dihydrotestosterone Plasma Levels in Adult Male Rats","abstract":"<jats:p>In the present study we investigated the effects of castration on androstenedione (A), testosterone (T) and dihydrotestosterone (DHT) plasma levels in adult male rats 5 and 47 days after castration. In another group of 60-day-old castrated rats, the three steroids have been evaluated during testosterone propionate administration. Our data show that 5 days after orchiectomy all three steroids were significantly decreased (p &lt; 0.001) with respect to control values. 47 days after orchiectomy, T and DHT were also significantly decreased with respect to the control group. In both groups of orchiectomized rats the A/T ratio increased significantly with respect to controls. On the contrary, the T/DHT ratio sharply decreased. This suggests that DHT, in orchiectomized rats, could derive from precursors other than T A negative correlation between A and the T/DHT ratio was observed 47 days after castration in adult animals and emphasized upon testosterone propionate administration. In the latter group, T was significantly lower while A is significantly augmented with respect to control values. Finally, the above-mentioned negative correlation indicates a possible prevalent role of A in contributing to the circulating levels of DHT in adult orchiectomized rats.</jats:p>","journal":"Hormone Research","year":2008,"id":38715,"datarank":0.9257821989349548,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.5530462014667546,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.5530462014667546,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":9,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":191624,"name":"C. Giacchetto","orcid":null,"position":1,"is_corresponding":false},{"id":191625,"name":"M. Canonaco","orcid":null,"position":2,"is_corresponding":false},{"id":191626,"name":"S. Aquila","orcid":null,"position":3,"is_corresponding":false},{"id":191627,"name":"A. Valenti","orcid":null,"position":4,"is_corresponding":false},{"id":191628,"name":"E. Beraldi","orcid":null,"position":5,"is_corresponding":false},{"id":191629,"name":"A. Piro","orcid":null,"position":6,"is_corresponding":false},{"id":191630,"name":"F. Dessì-Fulgheri","orcid":null,"position":7,"is_corresponding":false},{"id":191623,"name":"S. Andò","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3943771","pmcid":null,"openalex_id":"https://openalex.org/W2091393566","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.20633887,"influential_citations":1,"citation_trend":[{"year":2012,"count":2},{"year":2017,"count":1},{"year":2019,"count":2}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://karger.com/article-pdf/doi/10.1159/000180299","host_type":"publisher"},{"url":"https://doi.org/10.1159/000180299","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3943771","host_type":"repository"}],"fields_of_study":["Hormonal and reproductive studies","Medicine","Biology","Androstenedione","Animals","Dihydrotestosterone","Male","Orchiectomy","Radioimmunoassay","Rats","Rats, Inbred Strains","Testosterone"],"mesh_terms":["Androstenedione","Animals","Male","Orchiectomy","Radioimmunoassay","Rats, Inbred Strains","Dihydrotestosterone","Testosterone","Rats"],"keywords":["Androstenedione","Testosterone (patch)","Castration","Dihydrotestosterone","Internal medicine","Endocrinology","Adult male","Androgen","Chemistry","Medicine","Hormone"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T05:30:24.598313Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}