{"doi":"10.1159/000126317","title":"Immunocytochemical Localization of Insulin-Like Growth Factor I in the Hypothalamo-Hypophyseal System of the Adult Rat","abstract":"<jats:p>Insulin-like growth factor I (IGF-I) is shown to be involved in the regulation of pituitary hormones. High IGF-I concentrations were detected in hypothalamus and pituitary during adulthood. This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures. IGF-I was found to be widely distributed throughout the hypothalamus; it was present in the magnocellular neurons of the supraoptic, paraventricular, and accessory nuclei. Moreover, nerve fibres and puncta containing immunoreactive IGF-I were localized in the median eminence and the posterior lobe of the pituitary. These results support possible IGF-I neuromodulatory or neurohormonal action in the hypothalamus on pituitary hormone regulation.</jats:p>","journal":"Neuroendocrinology","year":2008,"id":16560,"datarank":0.8748853332096804,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.449903331601248,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.449903331601248,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":13,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":121784,"name":"Teresa Fernández","orcid":null,"position":1,"is_corresponding":false},{"id":121785,"name":"Ricardo Martínez-Murillo","orcid":null,"position":2,"is_corresponding":false},{"id":121786,"name":"José Rodrigo","orcid":null,"position":3,"is_corresponding":false},{"id":121787,"name":"Lucinda Cacicedo","orcid":null,"position":4,"is_corresponding":false},{"id":121788,"name":"Franco Sánchez-Franco","orcid":null,"position":5,"is_corresponding":false},{"id":121783,"name":"Fernando Aguado","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1369595","pmcid":null,"openalex_id":"https://openalex.org/W2092490499","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.20742429,"influential_citations":1,"citation_trend":[{"year":2012,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/126317","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000126317","host_type":"publisher"},{"url":"https://doi.org/10.1159/000126317","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1369595","host_type":"repository"},{"url":"http://hdl.handle.net/10261/67138","host_type":"repository"}],"fields_of_study":["Growth Hormone and Insulin-like Growth Factors","Thyroid Disorders and Treatments","Biology","Medicine","Animals","Fluorescent Antibody Technique","Hypothalamo-Hypophyseal System","Hypothalamus","Immunohistochemistry","Insulin-Like Growth Factor I","Male","Neurons","Pituitary Gland","Rats","Rats, Wistar","Supraoptic Nucleus"],"mesh_terms":["Animals","Fluorescent Antibody Technique","Hypothalamo-Hypophyseal System","Hypothalamus","Immunohistochemistry","Insulin-Like Growth Factor I","Male","Neurons","Pituitary Gland","Supraoptic Nucleus","Rats, Wistar","Rats"],"keywords":["Median eminence","Hypothalamus","Internal medicine","Endocrinology","Immunocytochemistry","Insulin-like growth factor","Pituitary gland","Biology","Hormone","Somatomedin","Growth hormone","Growth factor","Medicine","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T11:29:59.833157Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}