{"doi":"10.1159/000125924","title":"Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty","abstract":"<jats:p>In both rats and primates, including humans, serum levels of insulin-like growth factor I (IGF-1) increase during the onset of puberty, suggesting a role for IGF-I in this process. We examined the ability of IGF-1 to affect the release of hypothalamic luteinizing hormone releasing hormone (LHRH) in prepubertal female rats. Our results indicate that IGF-I acts on the median eminence, which contains the highest density of type 1 IGF receptors in the brain, to elicit a dose-related increase in LHRH release. In this regard, a minimal effective dose of 10 ng/ml (p &lt; 0.05) and a maximal effective dose of 100 ng/ml (p &lt; 0.01) was observed. IGF-II and insulin were one order of magnitude less effective. The results demonstrate that IGF-I has the capability to act directly upon the median eminence to effect release of LHRH, thereby suggesting a role for IGF-I in facilitating peripubertal changes in LHRH release. Thus, IGF-I may represent one of the ‘metabolic signals’ thought to be involved in the initiation of puberty.</jats:p>","journal":"Neuroendocrinology","year":2008,"id":31281,"datarank":9.787839947474197,"base_score":5.41610040220442,"endowment":5.41610040220442,"self_citation_contribution":0.8124150603306631,"citation_network_contribution":8.975424887143534,"self_endowment_contribution":0.8124150603306631,"citer_contribution":8.975424887143534,"corpus_percentile":null,"corpus_rank":null,"citation_count":224,"citer_count":179,"citers_with_citation_signal":163,"citers_with_endowment":163,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":167996,"name":"Sergio R. Ojeda","orcid":null,"position":1,"is_corresponding":false},{"id":167997,"name":"Les Dees","orcid":null,"position":2,"is_corresponding":false},{"id":167993,"name":"Jill K. Hiney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.41610040220442,"endowment":5.41610040220442,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1758585","pmcid":null,"openalex_id":"https://openalex.org/W2088127887","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"HD25123","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"AA00104","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"AA07216","title":null}],"total_grants":3,"fwci":4.288,"citation_percentile":0.94963638,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":2},{"year":2014,"count":6},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":5},{"year":2022,"count":15},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/125924","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000125924","host_type":"publisher"},{"url":"https://doi.org/10.1159/000125924","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1758585","host_type":"repository"}],"fields_of_study":["Growth Hormone and Insulin-like Growth Factors","Animals","Female","Gonadotropin-Releasing Hormone","Insulin-Like Growth Factor I","Rats","Rats, Inbred Strains","Sexual Maturation","Signal Transduction"],"mesh_terms":["Animals","Female","Insulin-Like Growth Factor I","Gonadotropin-Releasing Hormone","Rats, Inbred Strains","Sexual Maturation","Signal Transduction","Rats"],"keywords":["Endocrinology","Internal medicine","Insulin-like growth factor","Growth factor","Biology","Medicine","Psychology","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.20296405.v1","title":"Additional file 1 of The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20296405","title":"Additional file 1 of The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20296408.v1","title":"Additional file 2 of The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20296408","title":"Additional file 2 of The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19641934","title":"Additional file 1 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19641937.v1","title":"Additional file 2 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19641940.v1","title":"Additional file 3 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19641937","title":"Additional file 2 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19641940","title":"Additional file 3 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.19641934.v1","title":"Additional file 1 of Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats","publisher":"figshare","resource_type":"Image"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T06:48:06.400639Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}