{"doi":"10.1159/000106648","title":"Excitatory Pattern of Gamma-Interferon on Natural Killer Cell Activity in Senile Dementia of the Alzheimer Type","abstract":"<jats:p>Spontaneous natural killer (NK) cell activity and NK-induced cytotoxicity after interferon-γ (IFN-γ) were measured in healthy elderly subjects and in patients with senile dementia of Alzheimer type (SDAT) and multi-infarct dementia (MID). Normal basal and IFN-γ-stimulated NK cytotoxicity were found in healthy old subjects and in patients with MID. On the contrary higher NK cytotoxicity after IFN-γ (650 IU) was demonstrated in SDAT patients than in MID and healthy subjects (p &lt; 0.001). A significant inverse correlation between the percent increase of NK cytotoxicity after IFN-γ and the Mini Mental State Examination score (p &lt; 0.001) was also demonstrated in patients with SDAT. Our data might suggest a cytokine-dependent mechanism of NK activation in SDAT associated with the neuroimmune hypothesis of the disease.</jats:p>","journal":"Dementia and Geriatric Cognitive Disorders","year":1997,"id":629437,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1630131,"name":"Marisa Fioravanti","orcid":null,"position":1,"is_corresponding":false},{"id":1630132,"name":"Silvia Severgnini","orcid":null,"position":2,"is_corresponding":false},{"id":1630133,"name":"Nunziata Pezza","orcid":null,"position":3,"is_corresponding":false},{"id":1630134,"name":"Mattia Locatelli","orcid":null,"position":4,"is_corresponding":false},{"id":1630135,"name":"Nadia Cerutti","orcid":null,"position":5,"is_corresponding":false},{"id":1630136,"name":"Federica Terenzi","orcid":null,"position":6,"is_corresponding":false},{"id":1630137,"name":"Ettore Ferrari","orcid":null,"position":7,"is_corresponding":false},{"id":1630130,"name":"Sebastiano Bruno Solerte","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Excitatory Pattern of Gamma-Interferon on Natural Killer Cell Activity in Senile Dementia of the Alzheimer Type","abstract":"<jats:p>Spontaneous natural killer (NK) cell activity and NK-induced cytotoxicity after interferon-γ (IFN-γ) were measured in healthy elderly subjects and in patients with senile dementia of Alzheimer type (SDAT) and multi-infarct dementia (MID). Normal basal and IFN-γ-stimulated NK cytotoxicity were found in healthy old subjects and in patients with MID. On the contrary higher NK cytotoxicity after IFN-γ (650 IU) was demonstrated in SDAT patients than in MID and healthy subjects (p &lt; 0.001). A significant inverse correlation between the percent increase of NK cytotoxicity after IFN-γ and the Mini Mental State Examination score (p &lt; 0.001) was also demonstrated in patients with SDAT. Our data might suggest a cytokine-dependent mechanism of NK activation in SDAT associated with the neuroimmune hypothesis of the disease.</jats:p>","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9298632","pmcid":null,"openalex_id":"https://openalex.org/W2026492037","authors":[],"funders":[],"total_grants":0,"fwci":2.4637,"citation_percentile":0.87042254,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://karger.com/pages/terms-and-conditions","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/106648","host_type":"publisher"},{"url":"https://karger.com/article-pdf/doi/10.1159/000106648","host_type":"publisher"},{"url":"https://doi.org/10.1159/000106648","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9298632","host_type":"repository"}],"fields_of_study":["Tryptophan and brain disorders","Neuroinflammation and Neurodegeneration Mechanisms","Immune Cell Function and Interaction","Adult","Aged","Alzheimer Disease","Cell Line","Cytotoxicity Tests, Immunologic","Dementia, Multi-Infarct","Female","Humans","Interferon-gamma","Killer Cells, Natural","Male","Psychiatric Status Rating Scales","Recombinant Proteins"],"mesh_terms":["Adult","Aged","Alzheimer Disease","Cell Line","Cytotoxicity Tests, Immunologic","Female","Humans","Interferon-gamma","Killer Cells, Natural","Male","Psychiatric Status Rating Scales","Recombinant Proteins","Dementia, Multi-Infarct"],"keywords":["Interferon gamma","Cytotoxicity","Natural killer cell","Dementia","Alzheimer's disease","Cytokine","Immunology","Interferon","Senile plaques","Medicine","Disease","Internal medicine","Biology","In vitro","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T18:37:10.517090Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}