{"doi":"10.1159/000092464","title":"Changes in the Approach for Invasive Prenatal Diagnosis in 35,127 Cases at a Single Center from 1977 to 2004","abstract":"<jats:p>&lt;i&gt;Objectives:&lt;/i&gt; To evaluate the changes in the approaches used for invasive prenatal diagnosis for β-thalassemia and karyotyping at a single center from 1977 to 2004. &lt;i&gt;Methods:&lt;/i&gt; For β-thalassemia, in 1977 placentacentesis, in 1982 amniocentesis, in 1983 fetoscopy and cordocentesis, in 1983 trancervical chorionic villi sampling (TC-CVS), in 1984 cardiocentesis, in 1986 transabdominal CVS, and in 2002 preimplantation genetic diagnosis (PGD) were introduced. For karyotyping, in 1977 amniocentesis, in 1983 cordocentesis and cardiocentesis and TC-CVS, in 1986 TA-CVS and in 1991 hepatic vein sampling were introduced. Rates of approaches used were retrospectively considered, for 5 different groups (1977–1981; 1982–1985; 1986–1993; 1994–1999; 2000–2004). &lt;i&gt;Results:&lt;/i&gt; 35,127 invasive prenatal diagnoses were considered, and 42 PGD included. For β-thalassemia 6,547 diagnoses were performed and 42 PGD. Since 1986–1993, TA-CVS was the only approach used except for 42 PGD in the 2000–2004 group. For karyotyping 28,538 diagnoses were performed. Amniocentesis and TA-CVS have been the most frequently used in the last years, while cordocentesis and hepatic vein sampling have shown a decline after their introduction. &lt;i&gt;Conclusion:&lt;/i&gt; TA-CVS is now the only technique used for β-thalassemia. For karyotype, amniocentesis and TA-CVS are the most frequently used procedures. Obstetrical and laboratory experience, the availability of screening, and other individual factors, have influenced the choice, towards an earlier approach in pregnancy.</jats:p>","journal":"Fetal Diagnosis and Therapy","year":2006,"id":689949,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1802480,"name":"Maria A. Zoppi","orcid":null,"position":1,"is_corresponding":false},{"id":1802481,"name":"Carolina Axiana","orcid":null,"position":2,"is_corresponding":false},{"id":1802482,"name":"Rosa M. Ibba","orcid":null,"position":3,"is_corresponding":false},{"id":1771834,"name":"Giovanni Monni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Changes in the Approach for Invasive Prenatal Diagnosis in 35,127 Cases at a Single Center from 1977 to 2004","abstract":"<jats:p>&lt;i&gt;Objectives:&lt;/i&gt; To evaluate the changes in the approaches used for invasive prenatal diagnosis for β-thalassemia and karyotyping at a single center from 1977 to 2004. &lt;i&gt;Methods:&lt;/i&gt; For β-thalassemia, in 1977 placentacentesis, in 1982 amniocentesis, in 1983 fetoscopy and cordocentesis, in 1983 trancervical chorionic villi sampling (TC-CVS), in 1984 cardiocentesis, in 1986 transabdominal CVS, and in 2002 preimplantation genetic diagnosis (PGD) were introduced. For karyotyping, in 1977 amniocentesis, in 1983 cordocentesis and cardiocentesis and TC-CVS, in 1986 TA-CVS and in 1991 hepatic vein sampling were introduced. Rates of approaches used were retrospectively considered, for 5 different groups (1977–1981; 1982–1985; 1986–1993; 1994–1999; 2000–2004). &lt;i&gt;Results:&lt;/i&gt; 35,127 invasive prenatal diagnoses were considered, and 42 PGD included. For β-thalassemia 6,547 diagnoses were performed and 42 PGD. Since 1986–1993, TA-CVS was the only approach used except for 42 PGD in the 2000–2004 group. For karyotyping 28,538 diagnoses were performed. Amniocentesis and TA-CVS have been the most frequently used in the last years, while cordocentesis and hepatic vein sampling have shown a decline after their introduction. &lt;i&gt;Conclusion:&lt;/i&gt; TA-CVS is now the only technique used for β-thalassemia. For karyotype, amniocentesis and TA-CVS are the most frequently used procedures. Obstetrical and laboratory experience, the availability of screening, and other individual factors, have influenced the choice, towards an earlier approach in pregnancy.</jats:p>","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16757910","pmcid":null,"openalex_id":"https://openalex.org/W1976498468","authors":[],"funders":[],"total_grants":0,"fwci":1.6574,"citation_percentile":0.85383612,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/92464","host_type":"publisher"},{"url":"https://doi.org/10.1159/000092464","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16757910","host_type":"repository"}],"fields_of_study":["Prenatal Screening and Diagnostics","Hemoglobinopathies and Related Disorders","Blood groups and transfusion","Chorionic Villi Sampling","Female","Humans","Karyotyping","Pregnancy","Prenatal Diagnosis","Time Factors","beta-Thalassemia"],"mesh_terms":["Female","Humans","Karyotyping","Pregnancy","Prenatal Diagnosis","Time Factors","Chorionic Villi Sampling","beta-Thalassemia"],"keywords":["Amniocentesis","Chorionic villus sampling","Prenatal diagnosis","Medicine","Obstetrics","Pregnancy","Thalassemia","Gynecology","Medical diagnosis","Beta thalassemia","Fetus","Internal medicine","Radiology","Genetics","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-22T19:09:06.418672Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}