{"doi":"10.1159/000070473","title":"Role of IgE in Th2 Cell-Mediated Allergic Airway Inflammation","abstract":"<jats:p>Recent studies with gene knockout mice have demonstrated that T helper 2 (Th2) cell-derived cytokines, including IL-4, IL-5, and IL-13, play important roles in causing allergic airway inflammation. In addition to Th2 cytokines, IgE-dependent activation of mast cells has been suggested to play a role in allergic airway inflammation. In this review, we will discuss the role of IgE in Th2 cell-mediated allergic airway inflammation. We used IgE transgenic mice, which enabled us to investigate the role of IgE without the influence of activated T cells and other immunoglobulins. Whereas IgE cross-linking by antigens did not induce eosinophil recruitment into the airways or airway hyperreactivity, IgE cross-linking induced CD4+ T cell recruitment into the airways. In addition, when antigen-specific Th2 cells were transferred to IgE transgenic mice, IgE cross-linking significantly enhanced antigen-induced eosinophil recruitment into the airways. These findings suggest that IgE-dependent mast cell activation plays an important role in allergic airway inflammation by recruiting Th2 cells into the site of allergic inflammation.</jats:p>","journal":"International Archives of Allergy and Immunology","year":2003,"id":632569,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242305,"name":"Hiroshi Nakajima","orcid":"0000-0001-8595-9381","position":1,"is_corresponding":false},{"id":1639767,"name":"Kotaro Kumano","orcid":null,"position":2,"is_corresponding":false},{"id":824614,"name":"Shuichi Kubo","orcid":null,"position":3,"is_corresponding":false},{"id":695177,"name":"Hajime Karasuyama","orcid":"0000-0003-0689-0836","position":4,"is_corresponding":false},{"id":1639773,"name":"Itsuo Iwamoto","orcid":null,"position":5,"is_corresponding":false},{"id":1639764,"name":"Yuko Maezawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Role of IgE in Th2 Cell-Mediated Allergic Airway Inflammation","abstract":"<jats:p>Recent studies with gene knockout mice have demonstrated that T helper 2 (Th2) cell-derived cytokines, including IL-4, IL-5, and IL-13, play important roles in causing allergic airway inflammation. In addition to Th2 cytokines, IgE-dependent activation of mast cells has been suggested to play a role in allergic airway inflammation. In this review, we will discuss the role of IgE in Th2 cell-mediated allergic airway inflammation. We used IgE transgenic mice, which enabled us to investigate the role of IgE without the influence of activated T cells and other immunoglobulins. Whereas IgE cross-linking by antigens did not induce eosinophil recruitment into the airways or airway hyperreactivity, IgE cross-linking induced CD4+ T cell recruitment into the airways. In addition, when antigen-specific Th2 cells were transferred to IgE transgenic mice, IgE cross-linking significantly enhanced antigen-induced eosinophil recruitment into the airways. These findings suggest that IgE-dependent mast cell activation plays an important role in allergic airway inflammation by recruiting Th2 cells into the site of allergic inflammation.</jats:p>","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12771541","pmcid":null,"openalex_id":"https://openalex.org/W1993464074","authors":[],"funders":[],"total_grants":0,"fwci":1.0765,"citation_percentile":0.7464177,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/70473","host_type":"publisher"},{"url":"https://doi.org/10.1159/000070473","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12771541","host_type":"repository"}],"fields_of_study":["Asthma and respiratory diseases","Allergic Rhinitis and Sensitization","Eosinophilic Esophagitis","Animals","Cross Reactions","Cytokines","Humans","Immunoglobulin E","Pneumonia","Respiratory Hypersensitivity","Th2 Cells"],"mesh_terms":["Animals","Cross Reactions","Humans","Immunoglobulin E","Pneumonia","Respiratory Hypersensitivity","Cytokines","Th2 Cells"],"keywords":["Immunoglobulin E","Immunology","Eosinophil","Allergic inflammation","Inflammation","Allergy","Medicine","Antigen","Interleukin 5","Antibody","Cytokine","Interleukin","Asthma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:59:22.021335Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}