{"doi":"10.1159/000045299","title":"Differential Distribution of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Proteins in Experimental Diabetic Rat Kidney","abstract":"<jats:p>Insulin-like growth factor-1 (IGF-1) is a peptide growth factor, and its activity is modulated by interaction with the family of IGF binding proteins (IGFBP-1 to 6). IGF-1 is detected in rat kidney and has metabolic and growth effects. To explore the possible involvement of IGFBPs in glomerular hypertrophy in streptozotocin (STZ)-induced diabetic rat, the immunolocalization of IGF-1 and IGFBPs were investigated. IGF-1 was gradually increased in the glomeruli of diabetic rats and correlated with glomerular hypertrophy. IGFBP-1 was transiently increased at 1 week after the STZ injection and declined to control level during the following period. In contrast, IGFBP-4 was increased in the diabetic glomeruli throughout the observation period. With insulin treatment, the levels of IGF-1, IGFBP-1 and 4 were normalized and glomerular hypertrophy was prevented. Initial glomerular hypertrophy of diabetic nephropathy is a related IGF-1 action, which may be modulated by IGFBP-1 and 4.</jats:p>","journal":"Nephron","year":1999,"id":40437,"datarank":1.081248407129329,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.6395825602543627,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.6395825602543627,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":16,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196468,"name":"Kenichi Shikata","orcid":null,"position":1,"is_corresponding":false},{"id":196469,"name":"Jun Wada","orcid":null,"position":2,"is_corresponding":false},{"id":196470,"name":"Hikaru Sugimoto","orcid":null,"position":3,"is_corresponding":false},{"id":196471,"name":"Shin-Ichiro Takahashi","orcid":null,"position":4,"is_corresponding":false},{"id":196472,"name":"Hirofumi Makino","orcid":null,"position":5,"is_corresponding":false},{"id":196467,"name":"Nobuyuki Miyatake","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10050087","pmcid":null,"openalex_id":"https://openalex.org/W2032111989","authors":[],"funders":[],"total_grants":0,"fwci":0.5744,"citation_percentile":0.6395919,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2022,"count":1},{"year":2023,"count":2}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/45299","host_type":"publisher"},{"url":"https://doi.org/10.1159/000045299","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10050087","host_type":"repository"}],"fields_of_study":["Growth Hormone and Insulin-like Growth Factors","Metabolism, Diabetes, and Cancer","Genetic Syndromes and Imprinting","Medicine","Animals","Diabetes Mellitus, Experimental","Diabetic Nephropathies","Hypertrophy","Immunohistochemistry","Insulin","Insulin-Like Growth Factor Binding Protein 1","Insulin-Like Growth Factor Binding Protein 4","Insulin-Like Growth Factor Binding Proteins","Insulin-Like Growth Factor I","Kidney Glomerulus","Male","Rats","Rats, Sprague-Dawley","Tissue Distribution"],"mesh_terms":["Animals","Diabetes Mellitus, Experimental","Diabetic Nephropathies","Hypertrophy","Immunohistochemistry","Insulin","Insulin-Like Growth Factor I","Kidney Glomerulus","Male","Tissue Distribution","Rats, Sprague-Dawley","Insulin-Like Growth Factor Binding Proteins","Insulin-Like Growth Factor Binding Protein 1","Insulin-Like Growth Factor Binding Protein 4","Rats"],"keywords":["Internal medicine","Endocrinology","Diabetic nephropathy","Renal Hypertrophy","Insulin-like growth factor-binding protein","Medicine","Growth factor","Muscle hypertrophy","Kidney","Insulin","Insulin-like growth factor","Nephropathy","Diabetes mellitus","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T06:07:22.954260Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}