{"doi":"10.1159/000031029","title":"Search for the Sialic Acid–Independent Receptor on Red Blood Cells for Invasion by Plasmodium falciparum","abstract":null,"journal":"Vox Sanguinis","year":1999,"id":592976,"datarank":1.0407190533105366,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.6448604538682478,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.6448604538682478,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":10,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1517528,"name":"Marion E. Reid","orcid":null,"position":1,"is_corresponding":false},{"id":438062,"name":"Osamu Kaneko","orcid":"0000-0003-0675-8296","position":2,"is_corresponding":false},{"id":333594,"name":"Louis H. Miller","orcid":"0000-0002-3709-0092","position":3,"is_corresponding":false},{"id":1517526,"name":"Sandrine C. Soubes","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Search for the Sialic Acid–Independent Receptor on Red Blood Cells for Invasion by Plasmodium falciparum","abstract":"BACKGROUND AND OBJECTIVES: Plasmodium falciparum uses multiple red blood cell (RBC) receptors and parasite ligands to invade RBCs. One pathway uses a sialic acid-independent protein or carbohydrate for invasion. The present study searches for this RBC receptor. MATERIALS AND METHODS: We determined whether antigen-negative and null RBCs (including PNH cells that lack all glycosylphosphatidyl inositol-linked proteins) could be invaded after neuraminidase treatment. We used two P. falciparum clones for the study: one that requires sialic acid for invasion and was an indication of removal of sialic acid and a second clone that can invade neuraminidase-treated RBCs. RESULTS: All neuraminidase-treated variant RBCs in this study were invaded. CONCLUSION: This study indicates that some molecule other than those studied (e.g., a carbohydrate) is the receptor for the sialic acid-independent pathway. This powerful tool for the identification of receptors for microorganisms should be used more extensively.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10085527","pmcid":null,"openalex_id":"https://openalex.org/W2159692823","authors":[],"funders":[],"total_grants":0,"fwci":1.1625,"citation_percentile":0.81668426,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.karger.com/Article/Pdf/31029","host_type":"publisher"},{"url":"https://doi.org/10.1159/000031029","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10085527","host_type":"repository"}],"fields_of_study":["Malaria Research and Control","Glycosylation and Glycoproteins Research","vaccines and immunoinformatics approaches"],"mesh_terms":["Animals","Cells, Cultured","Erythrocytes","Humans","Isoantigens","Neuraminidase","Plasmodium falciparum","Receptors, Cell Surface","N-Acetylneuraminic Acid"],"keywords":["Sialic acid","Neuraminidase","Plasmodium falciparum","Receptor","N-Acetylneuraminic acid","Biology","Red blood cell","Biochemistry","clone (Java method)","Microbiology","Immunology","Malaria","Gene","Enzyme"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:30:23.651487Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}