{"doi":"10.1159/000023450","title":"Nociceptin Stimulates Thyrotropin Secretion in Rats","abstract":"<jats:p>Effects of nociceptin on thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion in rats were studied. Nociceptin (150 μg/kg) was injected intravenously and rats were serially decapitated after the injection. The effects of nociceptin on TRH release from the hypothalamus and TSH release from the anterior pituitary in vitro were also investigated. TRH and thyroid hormones were measured by individual radioimmunoassays. TSH was determined by enzyme immunoassay. TRH contents in the hypothalamus decreased significantly after nociceptin injection, whereas plasma TRH concentrations showed no changes. Plasma TSH concentrations increased significantly in a dose-related manner. The TRH release from the hypothalamus was enhanced significantly in a dose-related manner with the addition of nociceptin. The TSH release from the anterior pituitary in vitro was not affected by the addition of nociceptin. The plasma thyroxine and 3,3′,5-triiodothyronine levels did not change significantly after nociceptin administration. The inactivation of TRH by plasma or hypothalamus in vitro after nociceptin injection did not differ from that of controls. The findings suggest that nociceptin acts on the hypothalamus to stimulate TRH and TSH secretion.</jats:p>","journal":"Hormone Research in Paediatrics","year":1999,"id":615242,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1585662,"name":"Yoshifumi Hirooka","orcid":null,"position":1,"is_corresponding":false},{"id":1585663,"name":"Yuichi Mori","orcid":null,"position":2,"is_corresponding":false},{"id":1585664,"name":"Masato Kayama","orcid":null,"position":3,"is_corresponding":false},{"id":1585665,"name":"Koshin Adachi","orcid":null,"position":4,"is_corresponding":false},{"id":1585666,"name":"Nebi Rhue","orcid":null,"position":5,"is_corresponding":false},{"id":1585667,"name":"Jing Ping","orcid":null,"position":6,"is_corresponding":false},{"id":1585668,"name":"Rumiko Ikai","orcid":null,"position":7,"is_corresponding":false},{"id":1585669,"name":"Atsuko Nakayashiki","orcid":null,"position":8,"is_corresponding":false},{"id":1585670,"name":"Tsuyoshi Nogimori","orcid":null,"position":9,"is_corresponding":false},{"id":1585661,"name":"Terunori Mitsuma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nociceptin Stimulates Thyrotropin Secretion in Rats","abstract":"<jats:p>Effects of nociceptin on thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion in rats were studied. Nociceptin (150 μg/kg) was injected intravenously and rats were serially decapitated after the injection. The effects of nociceptin on TRH release from the hypothalamus and TSH release from the anterior pituitary in vitro were also investigated. TRH and thyroid hormones were measured by individual radioimmunoassays. TSH was determined by enzyme immunoassay. TRH contents in the hypothalamus decreased significantly after nociceptin injection, whereas plasma TRH concentrations showed no changes. Plasma TSH concentrations increased significantly in a dose-related manner. The TRH release from the hypothalamus was enhanced significantly in a dose-related manner with the addition of nociceptin. The TSH release from the anterior pituitary in vitro was not affected by the addition of nociceptin. The plasma thyroxine and 3,3′,5-triiodothyronine levels did not change significantly after nociceptin administration. The inactivation of TRH by plasma or hypothalamus in vitro after nociceptin injection did not differ from that of controls. The findings suggest that nociceptin acts on the hypothalamus to stimulate TRH and TSH secretion.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10725778","pmcid":null,"openalex_id":"https://openalex.org/W1988656905","authors":[],"funders":[],"total_grants":0,"fwci":0.2177,"citation_percentile":0.37784309,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2017,"count":1}],"oa_status":"closed","license":"https://www.karger.com/Services/SiteLicenses","oa_locations":[{"url":"https://www.karger.com/Article/Pdf/23450","host_type":"publisher"},{"url":"https://doi.org/10.1159/000023450","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10725778","host_type":"repository"}],"fields_of_study":["Neuropeptides and Animal Physiology","Hypothalamic control of reproductive hormones","Receptor Mechanisms and Signaling"],"mesh_terms":["Nociceptin","Animals","Dose-Response Relationship, Drug","Hypothalamus","Male","Pituitary Gland, Anterior","Thyrotropin","Thyrotropin-Releasing Hormone","Thyroxine","Triiodothyronine","Rats, Wistar","Excitatory Amino Acids","Opioid Peptides","Rats"],"keywords":["Nociceptin receptor","Endocrinology","Internal medicine","Hypothalamus","Thyrotropin-releasing hormone","Hormone","Radioimmunoassay","TRH stimulation test","Chemistry","Peptide hormone","Anterior pituitary","Triiodothyronine","Secretion","Medicine","Opioid peptide","Receptor","Opioid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T19:27:14.137009Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}