{"doi":"10.1158/2159-8290.cd-24-0089","title":"Targeting Senescence for Next-Generation Cancer Treatments","abstract":"<jats:sec>\n                  <jats:title>Summary:</jats:title>\n                  <jats:p>Cellular senescence has paradoxical effects on cancer emergence, progression, and therapeutic response. We herein identify four lessons that emerged from studying senescence interaction with cancer and emphasize four bottlenecks in the therapeutic manipulation of cellular senescence to prevent or cure cancer.</jats:p>\n               </jats:sec>","journal":"Cancer Discovery","year":2024,"id":24098,"datarank":0.40506136788539604,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.09314513663342064,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.09314513663342064,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145670,"name":"Pierre Soubeyran","orcid":"0000-0003-3244-7299","position":1,"is_corresponding":false},{"id":145671,"name":"Eric Solary","orcid":"0000-0002-8629-1341","position":2,"is_corresponding":false},{"id":145669,"name":"Eric Gilson","orcid":"0000-0001-5738-6723","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38571431","pmcid":null,"openalex_id":"https://openalex.org/W4393943790","authors":[],"funders":[],"total_grants":0,"fwci":2.1013,"citation_percentile":0.86868595,"influential_citations":1,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://aacrjournals.org/cancerdiscovery/article-pdf/14/4/635/3434762/635.pdf","host_type":"journal"},{"url":"https://aacrjournals.org/cancerdiscovery/article-pdf/14/4/635/3434762/635.pdf","host_type":"BRONZE"},{"url":"https://aacrjournals.org/cancerdiscovery/article-pdf/14/4/635/3434762/635.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1158/2159-8290.cd-24-0089","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38571431","host_type":"repository"}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Advanced biosensing and bioanalysis techniques","Advanced Fluorescence Microscopy Techniques","Medicine","Biology","Humans","Cellular Senescence","Neoplasms"],"mesh_terms":["Humans","Neoplasms","Cellular Senescence"],"keywords":["Senescence","Cellular senescence","Cancer","Biology","Cancer cell","Cancer research","Computational biology","Cell biology","Genetics","Gene","Phenotype"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T21:30:02.368437Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}