{"doi":"10.1158/2159-8290.c.6549963","title":"Data from CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma","abstract":"<div>Abstract<p>To address antigen escape and loss of T-cell functionality, we report a phase I clinical trial (NCT04007029) evaluating autologous naive and memory T (T<sub>N/MEM</sub>) cells engineered to express a bispecific anti-CD19/CD20 chimeric antigen receptor (CAR; CART19/20) for patients with relapsed/refractory non-Hodgkin lymphoma (NHL), with safety as the primary endpoint. Ten patients were treated with 36 × 10<sup>6</sup> to 165 × 10<sup>6</sup> CART19/20 cells. No patient experienced neurotoxicity of any grade or over grade 1 cytokine release syndrome. One case of dose-limiting toxicity (persistent cytopenia) was observed. Nine of 10 patients achieved objective response [90% overall response rate (ORR)], with seven achieving complete remission [70% complete responses (CR) rate]. One patient relapsed after 18 months in CR but returned to CR after receiving a second dose of CART19/20 cells. Median progression-free survival was 18 months and median overall survival was not reached with a 17-month median follow-up. In conclusion, CART19/20 T<sub>N/MEM</sub> cells are safe and effective in patients with relapsed/refractory NHL, with durable responses achieved at low dosage levels.</p>Significance:<p>Autologous CD19/CD20 bispecific CAR-T cell therapy generated from T<sub>N/MEM</sub> cells for patients with NHL is safe (no neurotoxicity, maximum grade 1 cytokine release syndrome) and demonstrates strong efficacy (90% ORR, 70% CR rate) in a first-in-human, phase I dose-escalation trial.</p><p><a href=\"https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-13-3-ITI\" target=\"_blank\">This article is highlighted in the In This Issue feature, p. 517</a></p></div>","journal":null,"year":2023,"id":405882,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":849706,"name":"Christopher M. 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Ghafouri","orcid":"0000-0002-1610-220X","position":3,"is_corresponding":false},{"id":849709,"name":"Jacob Naparstek","orcid":"0000-0002-2047-4532","position":4,"is_corresponding":false},{"id":849710,"name":"Jacqueline Trent","orcid":"0000-0002-3726-4646","position":5,"is_corresponding":false},{"id":582318,"name":"Jia Ming Chen","orcid":"0000-0003-3992-9143","position":6,"is_corresponding":false},{"id":849711,"name":"Mobina Roshandell","orcid":"0000-0002-7073-6617","position":7,"is_corresponding":false},{"id":849712,"name":"Caitlin Harris","orcid":"0000-0003-2325-1729","position":8,"is_corresponding":false},{"id":558921,"name":"Mobina Khericha","orcid":"0000-0002-6734-7741","position":9,"is_corresponding":false},{"id":849713,"name":"Thomas Schweppe","orcid":"0000-0003-4541-8403","position":10,"is_corresponding":false},{"id":226358,"name":"Beata Berent-Maoz","orcid":"0000-0002-5972-9029","position":11,"is_corresponding":false},{"id":849714,"name":"Stanley B. 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Young","orcid":"0000-0002-2161-9377","position":20,"is_corresponding":false},{"id":849718,"name":"Caspian Oliai","orcid":"0000-0002-6368-8557","position":21,"is_corresponding":false},{"id":708715,"name":"Gary J. Schiller","orcid":"0000-0002-7508-3467","position":22,"is_corresponding":false},{"id":11106,"name":"John M. Timmerman","orcid":"0000-0003-4104-8943","position":23,"is_corresponding":false},{"id":58599,"name":"Antoni Ribas","orcid":"0000-0003-3669-8458","position":24,"is_corresponding":false},{"id":231695,"name":"Yvonne Y. Chen","orcid":"0000-0002-5583-119X","position":25,"is_corresponding":false},{"id":636363,"name":"Sarah Larson","orcid":"0000-0002-4335-2925","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:20:59.152593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}