{"doi":"10.1158/1078-0432.c.6529904","title":"Data from Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET","abstract":"<div>AbstractPurpose:<p>We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, [<sup>89</sup>Zr]DFO-YS5, and evaluated its performance for immunoPET imaging in murine prostate cancer models.</p>Experimental Design:<p>[<sup>89</sup>Zr]DFO-YS5 was prepared and its <i>in vitro</i> binding affinity for CD46 was measured. ImmunoPET imaging was conducted in male athymic nu/nu mice bearing DU145 [AR<sup>−</sup>, CD46<sup>+</sup>, prostate-specific membrane antigen–negative (PSMA<sup>−</sup>)] or 22Rv1 (AR<sup>+</sup>, CD46<sup>+</sup>, PSMA<sup>+</sup>) tumors, and in NOD/SCID gamma mice bearing patient-derived adenocarcinoma xenograft, LTL-331, and neuroendocrine prostate cancers, LTL-331R and LTL-545.</p>Results:<p>[<sup>89</sup>Zr]DFO-YS5 binds specifically to the CD46-positive human prostate cancer DU145 and 22Rv1 xenografts. In biodistribution studies, the tumor uptake of [<sup>89</sup>Zr]DFO-YS5 was 13.3 ± 3.9 and 11.2 ± 2.5 %ID/g, respectively, in DU145 and 22Rv1 xenografts, 4 days postinjection. Notably, [<sup>89</sup>Zr]DFO-YS5 demonstrated specific uptake in the PSMA- and AR-negative DU145 model. [<sup>89</sup>Zr]DFO-YS5 also showed uptake in the patient-derived LTL-331 and -331R models, with particularly high uptake in the LTL-545 neuroendocrine prostate cancer tumors (18.8 ± 5.3, 12.5 ± 1.8, and 32 ± 5.3 %ID/g in LTL-331, LTL-331R, and LTL-545, respectively, at 4 days postinjection).</p>Conclusions:<p>[<sup>89</sup>Zr]DFO-YS5 is an excellent PET imaging agent across a panel of prostate cancer models, including in both adenocarcinoma and neuroendocrine prostate cancer, both cell line- and patient-derived xenografts, and both PSMA-positive and -negative tumors. It demonstrates potential for clinical translation as an imaging agent, theranostic platform, and companion biomarker in prostate cancer.</p></div>","journal":null,"year":2023,"id":405709,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9106,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":465293,"name":"Jun Li","orcid":"0000-0002-7308-6576","position":1,"is_corresponding":false},{"id":341294,"name":"Jun Hua","orcid":"0000-0001-5481-7380","position":2,"is_corresponding":false},{"id":1184273,"name":"Yang Su","orcid":"0009-0004-2590-1654","position":3,"is_corresponding":false},{"id":401717,"name":"Denis Beckford-Vera","orcid":"0000-0003-3949-1495","position":4,"is_corresponding":false},{"id":465294,"name":"Walter Zhao","orcid":"0000-0001-8907-4935","position":5,"is_corresponding":false},{"id":466438,"name":"Mayuri Jayaraman","orcid":null,"position":6,"is_corresponding":false},{"id":465295,"name":"Tony L. 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Egusa","orcid":"0000-0003-2017-5708","position":16,"is_corresponding":false},{"id":370754,"name":"Jonathan Chou","orcid":"0000-0003-1258-0391","position":17,"is_corresponding":false},{"id":259327,"name":"Felix Y. Feng","orcid":"0000-0002-0963-7687","position":18,"is_corresponding":false},{"id":36081,"name":"Rahul Aggarwal","orcid":"0000-0001-7003-7982","position":19,"is_corresponding":false},{"id":465302,"name":"Michael J. Evans","orcid":"0000-0003-4947-1316","position":20,"is_corresponding":false},{"id":325839,"name":"Youngho Seo","orcid":"0000-0001-5908-6636","position":21,"is_corresponding":false},{"id":15500,"name":"Bin Liu","orcid":"0000-0002-9113-9694","position":22,"is_corresponding":false},{"id":272317,"name":"Robert R. 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