{"doi":"10.1158/1055-9965.c.6515155","title":"Data from Men with Low Serum Cholesterol Have a Lower Risk of High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial","abstract":"<div>Abstract<p>Background: Several prospective studies suggest that use of cholesterol-lowering statin drugs is inversely associated with advanced stage and possibly high-grade prostate cancer. One study reported that men with low cholesterol had a lower risk of high-grade prostate cancer. Given these findings, we investigated the association between low serum cholesterol and prostate cancer risk in the Prostate Cancer Prevention Trial.</p><p>Methods: We conducted a cohort study of 5,586 men ages ≥55 years who were randomized to the placebo arm of the Prostate Cancer Prevention Trial between 1993 and 1996. Serum cholesterol was measured enzymatically at entry. By the end of follow-up, 1,251 prostate cancer cases were confirmed. We used logistic regression to calculate the multivariable odds ratio (OR) of total, and Gleason 2 to 6 (<i>n</i> = 993), 7 (<i>n</i> = 199), and 8 to 10 (<i>n</i> = 59) prostate cancer comparing low serum (normal, <200 mg/dL) to high-serum (borderline and elevated cholesterol, ≥200 mg/dL) cholesterol.</p><p>Results: Men with low cholesterol had a lower risk of Gleason 8 to 10 prostate cancer [OR, 0.41; 95% confidence interval (CI), 0.22-0.77] than men with high cholesterol. No association was present for prostate cancer overall (OR, 0.97; 95% CI, 0.85-1.11), Gleason 2 to 6 disease (OR, 1.03; 95% CI, 0.89-1.18), or Gleason 7 disease (OR, 0.93; 95% CI, 0.69-1.24).</p><p>Conclusion: These prospective results support that men with low cholesterol have a reduced risk of high-grade prostate cancer. These and other contemporary data that suggest that cholesterol metabolism should be investigated further in the etiology of prostate cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2807–13)</p></div>","journal":null,"year":2023,"id":404606,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571530,"name":"Cathee Till","orcid":"0000-0002-6801-8333","position":1,"is_corresponding":false},{"id":344379,"name":"Phyllis J. Goodman","orcid":"0000-0001-9660-7074","position":2,"is_corresponding":false},{"id":218402,"name":"Howard L. Parnes","orcid":"0000-0003-3401-0007","position":3,"is_corresponding":false},{"id":377008,"name":"William D. Figg","orcid":"0000-0002-5875-2606","position":4,"is_corresponding":false},{"id":218606,"name":"Demetrius Albanes","orcid":"0000-0001-8330-4293","position":5,"is_corresponding":false},{"id":27761,"name":"Marian L. Neuhouser","orcid":"0000-0002-3876-0000","position":6,"is_corresponding":false},{"id":318042,"name":"Eric A. Klein","orcid":"0000-0002-1783-0698","position":7,"is_corresponding":false},{"id":420935,"name":"Ian M. Thompson","orcid":"0000-0003-0833-952X","position":8,"is_corresponding":false},{"id":1182409,"name":"Alan R. Kristal","orcid":"0000-0002-7329-1617","position":9,"is_corresponding":false},{"id":218634,"name":"Elizabeth A. Platz","orcid":"0000-0003-3676-8954","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:20:44.591715Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}