{"doi":"10.1158/1055-9965.c.6515004","title":"Data from Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone–Binding Globulin","abstract":"<div>Abstract<p><b>Background:</b> Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder.</p><p><b>Methods:</b> To investigate their biological basis, we examined the possible association between 164 single nucleotide polymorphisms (SNPs) in the 8q24 risk regions spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, 3αdiol G, and bioavailable testosterone), and sex hormone–binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial). Age-adjusted linear regression models were used to determine the association between the SNPs in an additive genetic model and log-transformed biomarker levels.</p><p><b>Results:</b> Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (<i>P</i> < 1.1 × 10<sup>−3</sup>) and bioavailable testosterone (<i>P</i> < 6.3 × 10<sup>−4</sup>). Suggestive associations were seen for a cluster of nine SNPs in prostate cancer risk region 1 and androstenedione (<i>P</i> < 0.05).</p><p><b>Conclusions:</b> These preliminary findings require confirmation in larger studies but raise the intriguing hypothesis that genetic variations in the 8q24 cancer risk regions might correlate with androgen levels.</p><p><b>Impact:</b> These results might provide some clues for the strong link between 8q24 and prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 19(7); 1848–54. ©2010 AACR.</p></div>","journal":null,"year":2023,"id":404608,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":823064,"name":"Tamra E. Meyer","orcid":null,"position":1,"is_corresponding":false},{"id":422441,"name":"Qizhai Li","orcid":"0000-0002-3325-8265","position":2,"is_corresponding":false},{"id":104449,"name":"Idan Menashe","orcid":"0000-0003-1961-1461","position":3,"is_corresponding":false},{"id":260582,"name":"Kai Yu","orcid":"0000-0002-5337-137X","position":4,"is_corresponding":false},{"id":24057,"name":"Philip S. Rosenberg","orcid":"0000-0001-6349-9126","position":5,"is_corresponding":false},{"id":241825,"name":"Wen‐Yi Huang","orcid":"0000-0002-4440-3368","position":6,"is_corresponding":false},{"id":888985,"name":"Sabah M. Quraishi","orcid":null,"position":7,"is_corresponding":false},{"id":317204,"name":"Rudolf Kaaks","orcid":"0000-0003-3751-3929","position":8,"is_corresponding":false},{"id":1182901,"name":"Jocelyn M. Weiss","orcid":null,"position":9,"is_corresponding":false},{"id":265961,"name":"Richard B. Hayes","orcid":"0000-0002-0918-661X","position":10,"is_corresponding":false},{"id":6431,"name":"Stephen J. Chanock","orcid":"0000-0002-2324-3393","position":11,"is_corresponding":false},{"id":32141,"name":"Ann W. Hsing","orcid":"0000-0003-0756-3511","position":12,"is_corresponding":false},{"id":593989,"name":"Lisa W. Chu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:20:44.591715Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}