{"doi":"10.1158/1055-9965.c.6514860","title":"Data from Telomere Length and &lt;i&gt;TERT&lt;/i&gt; Functional Polymorphisms Are Not Associated with Risk of Squamous Cell Carcinoma of the Head and Neck","abstract":"&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Recent studies reported associations of the relative telomere length (RTL) and &lt;i&gt;TERT&lt;/i&gt; variants with risk of several cancers, which have not been comprehensively investigated in squamous cell carcinoma of the head and neck (SCCHN).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We detected RTL in peripheral blood lymphocytes and genotyped six selected functional single-nucleotide polymorphisms (SNP) of the &lt;i&gt;TERT&lt;/i&gt; gene in 888 SCCHN cases and 885 cancer-free controls of non-Hispanic whites.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Overall, we did not observe significant associations between RTL and SCCHN risk (adjusted OR = 0.97; 95% CI = 0.80–1.17 for below versus above the median; &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt; = 0.618) nor between the six &lt;i&gt;TERT&lt;/i&gt; SNPs and SCCHN risk. We also found no associations between RTL and &lt;i&gt;TERT&lt;/i&gt; SNPs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our results suggest that RTL and &lt;i&gt;TERT&lt;/i&gt; functional polymorphisms may not play a major role in the etiology of SCCHN. Large prospective studies are needed to validate our findings.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; Although our results suggest no association among RTL, &lt;i&gt;TERT&lt;/i&gt; functional polymorphisms, and SCCHN risk, this study may contribute to future meta-analysis. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 20(12); 2642–5. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;","journal":null,"year":2023,"id":404632,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8372,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":93832,"name":"Hongxia Ma","orcid":"0000-0003-0165-4412","position":1,"is_corresponding":false},{"id":609988,"name":"Sheng Wei","orcid":"0000-0001-6888-6301","position":2,"is_corresponding":false},{"id":265956,"name":"Guojun Li","orcid":"0000-0001-9505-1502","position":3,"is_corresponding":false},{"id":265095,"name":"Erich M. Sturgis","orcid":null,"position":4,"is_corresponding":false},{"id":347037,"name":"Qingyi Wei","orcid":"0000-0002-3845-9445","position":5,"is_corresponding":false},{"id":349179,"name":"Zhensheng Liu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T01:20:44.591715Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}