{"doi":"10.1158/0008-5472.can-17-0307","title":"TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells","abstract":"Recent clinical successes of cancer immunotherapy necessitate the investigation of the interaction between malignant cells and the host immune system. However, elucidation of complex tumor-immune interactions presents major computational and experimental challenges. Here, we present Tumor Immune Estimation Resource (TIMER; cistrome.shinyapps.io/timer) to comprehensively investigate molecular characterization of tumor-immune interactions. Levels of six tumor-infiltrating immune subsets are precalculated for 10,897 tumors from 32 cancer types. TIMER provides 6 major analytic modules that allow users to interactively explore the associations between immune infiltrates and a wide spectrum of factors, including gene expression, clinical outcomes, somatic mutations, and somatic copy number alterations. TIMER provides a user-friendly web interface for dynamic analysis and visualization of these associations, which will be of broad utilities to cancer researchers. <i>Cancer Res; 77(21); e108-10. ©2017 AACR</i>.","journal":"Cancer Research","year":2017,"id":90,"datarank":16.103261894861483,"base_score":8.78523362361273,"endowment":8.78523362361273,"self_citation_contribution":1.3177850435419096,"citation_network_contribution":14.785476851319574,"self_endowment_contribution":1.3177850435419096,"citer_contribution":14.785476851319574,"corpus_percentile":86.6,"corpus_rank":2306,"citation_count":6536,"citer_count":196,"citers_with_citation_signal":196,"citers_with_endowment":196,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-10-31","authors":[{"id":665,"name":"Jingyu Fan","orcid":null,"position":1,"is_corresponding":false},{"id":666,"name":"Binbin Wang","orcid":"0000-0003-2885-6428","position":2,"is_corresponding":false},{"id":667,"name":"Nicole Traugh","orcid":"0000-0002-1194-8177","position":3,"is_corresponding":false},{"id":668,"name":"Qianming Chen","orcid":"0000-0002-5371-4432","position":4,"is_corresponding":false},{"id":32790,"name":"Jialiang Yang","orcid":"0000-0003-4689-8672","position":5,"is_corresponding":false},{"id":670,"name":"Bo Li","orcid":"0000-0002-8617-900X","position":6,"is_corresponding":false},{"id":671,"name":"X. Shirley Liu","orcid":"0000-0003-4736-7339","position":7,"is_corresponding":false},{"id":672,"name":"Jing‐Yu Fan","orcid":"0000-0003-2440-2015","position":8,"is_corresponding":false},{"id":664,"name":"Taiwen Li","orcid":"0000-0001-7940-8196","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}