{"doi":"10.1158/0008-5472.can-05-3427","title":"The <i>c-myc</i> Gene Is a Direct Target of Mammalian SWI/SNF–Related Complexes during Differentiation-Associated Cell Cycle Arrest","abstract":"The activity of mammalian SWI/SNF-related chromatin remodeling complexes is crucial for differentiation, development, and tumor suppression. Cell cycle-regulating activities dependent on the complexes include induction of the p21(WAF1/CIP1) kinase inhibitor and repression of E2F-responsive promoters. These responses are linked through effects on pRb phosphorylation, but the direct role of the SWI/SNF-related complexes in their regulation is not fully understood. Results presented here reveal that the complexes are required for regulation of a distinct pathway of proliferation control involving repression of c-myc expression in differentiating cells. This involves direct promoter targeting of the c-myc gene by the complexes. Induction of p21(WAF1/CIP1) is specifically dependent on prior repression of c-myc, but repression of E2F-responsive genes is dissociable from the regulation of c-myc and p21(WAF1/CIP1).","journal":"Cancer Research","year":2006,"id":1290,"datarank":6.428633001490827,"base_score":4.812184355372417,"endowment":4.812184355372417,"self_citation_contribution":0.7218276533058626,"citation_network_contribution":5.706805348184964,"self_endowment_contribution":0.7218276533058626,"citer_contribution":5.706805348184964,"corpus_percentile":null,"corpus_rank":null,"citation_count":122,"citer_count":117,"citers_with_citation_signal":106,"citers_with_endowment":106,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0453,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2006-02-01","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":16304,"name":"Daniel R. Zweitzig","orcid":null,"position":1,"is_corresponding":false},{"id":16305,"name":"Bayar Thimmapaya","orcid":"0000-0001-9842-5346","position":2,"is_corresponding":false},{"id":16306,"name":"George R. Beck","orcid":"0000-0002-7623-4095","position":3,"is_corresponding":false},{"id":16307,"name":"Elizabeth Moran","orcid":null,"position":4,"is_corresponding":false},{"id":16308,"name":"Elizabeth Morán","orcid":null,"position":5,"is_corresponding":false},{"id":16303,"name":"Norman G. Nagl","orcid":null,"position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}