{"doi":"10.1158/0008-5472.c.6567229","title":"Data from Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer","abstract":"<div>Abstract<p>Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we measured antibody levels [anti-spike (IgG-(S-RBD) and anti-nucleocapsid immunoglobulin] at three time points. Antibody level trajectories and frequency of breakthrough infections were evaluated by tumor type and timing of treatment relative to vaccination. IgG-(S-RBD) at peak response (median = 42 days after dose 2) was higher (<i>P</i> = 0.002) and remained higher after 4 to 6 months (<i>P</i> = 0.003) in patients receiving mRNA-1273 compared with BNT162b2. Patients with solid tumors attained higher peak levels (<i>P</i> = 0.001) and sustained levels after 4 to 6 months (<i>P</i> < 0.001) compared with those with hematologic malignancies. B-cell targeted treatment reduced peak (<i>P</i> = 0.001) and sustained antibody responses (<i>P</i> = 0.003). Solid tumor patients receiving immune checkpoint inhibitors before vaccination had lower sustained antibody levels than those who received treatment after vaccination (<i>P</i> = 0.043). Two (0.69%) vaccinated and one (1.9%) unvaccinated patient had severe COVID-19 illness during follow-up. Our study shows variation in sustained antibody responses across cancer populations receiving various therapeutic modalities, with important implications for vaccine booster timing and patient selection.</p>Significance:<p>Long-term studies of immunogenicity of SARS-CoV-2 vaccines in patients with cancer are needed to inform evidence-based guidelines for booster vaccinations and to tailor sequence and timing of vaccinations to elicit improved humoral responses.</p></div>","journal":null,"year":2023,"id":406217,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6723,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553328,"name":"Noah Merin","orcid":null,"position":1,"is_corresponding":false},{"id":282233,"name":"Omid Hamid","orcid":"0000-0002-8238-4655","position":2,"is_corresponding":false},{"id":441544,"name":"So Yung Choi","orcid":"0000-0002-1081-4951","position":3,"is_corresponding":false},{"id":665741,"name":"Tucker Lemos","orcid":null,"position":4,"is_corresponding":false},{"id":95051,"name":"Wendy Cozen","orcid":"0000-0003-3415-8247","position":5,"is_corresponding":false},{"id":1184901,"name":"Nathalie Huỳnh Châu Nguyễn","orcid":"0000-0002-5468-1759","position":6,"is_corresponding":false},{"id":665208,"name":"Laurel J. 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