{"doi":"10.1158/0008-5472.c.6500282","title":"Data from Concurrent Suppression of Integrin α<sub>5</sub>, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis","abstract":"<div>Abstract<p>miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include <i>integrin α<sub>5</sub></i> (<i>ITGA5</i>), <i>radixin</i> (<i>RDX</i>), and <i>RhoA</i>. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ectopically expressed miR-31 <i>in vivo</i>. However, these prior studies failed to investigate whether the combined suppression of the endogenous mRNAs encoding these three proteins recapitulated the <i>in vivo</i> consequences of miR-31 expression on metastasis. We show here that short hairpin RNA–mediated concurrent downregulation of ITGA5, RDX, and RhoA is sufficient to phenocopy the full spectrum of described influences of miR-31 on metastasis <i>in vivo</i>, including the effects of this microRNA (miRNA) on local invasion, early post-intravasation events, and metastatic colonization. These findings provide mechanistic insights into the metastatic process and have implications about the importance of pleiotropy for the biological actions of miRNAs. Cancer Res; 70(12); 5147–54. ©2010 AACR.</p></div>","journal":null,"year":2023,"id":404966,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":695806,"name":"Amelia Chang","orcid":null,"position":1,"is_corresponding":false},{"id":1183317,"name":"Nathan Benaich","orcid":"0000-0003-2213-6032","position":2,"is_corresponding":false},{"id":23815,"name":"Ferenc Reinhardt","orcid":null,"position":3,"is_corresponding":false},{"id":23828,"name":"Robert A. Weinberg","orcid":"0000-0002-0895-3557","position":4,"is_corresponding":false},{"id":1183682,"name":"Scott Valastyan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T01:20:49.237119Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}