{"doi":"10.1155/ah/9924808","title":"Treatment Patterns and Outcomes of Patients With Myelodysplastic Syndrome (MDS) by IPSS‐R Scores at Academic Cancer Centers","abstract":"This study describes treatment patterns and clinical and economic outcomes of patients with myelodysplastic syndrome (MDS) by Revised International Prognostic Scoring System (IPSS‐R) risk scores. A retrospective cohort study was conducted including adults diagnosed with MDS between 2010 and 2020 within two academic institutions. A total of 369 patients were included. Hypomethylating agents (HMAs) were used as first‐line therapy in 81% ( n = 230) and 51% ( n = 44) of higher‐risk (HR) and lower‐risk (LR) patients, respectively. Second‐line therapy was received by 24% of patients. Complete response was achieved by 11% of HR patients (median duration: 24 months). Median PFS and OS were 9.5 and 18.8 months in the HR cohort and 18.8 and 25.6 months in the LR cohort. Mean MDS‐related healthcare charges per patient per month were > 2‐fold higher among HR patients compared to LR ( p < 0.001). An unmet need exists for first and subsequent lines of therapy.","journal":"Advances in Hematology","year":2025,"id":535563,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1307935,"name":"Andre Hejazi","orcid":null,"position":1,"is_corresponding":false},{"id":1005164,"name":"Vonetta L. Williams","orcid":"0000-0001-5690-6707","position":2,"is_corresponding":false},{"id":1419641,"name":"Craig Comperatore","orcid":null,"position":3,"is_corresponding":false},{"id":906247,"name":"Srinivas K. Tantravahi","orcid":"0000-0003-4899-3796","position":4,"is_corresponding":false},{"id":1419180,"name":"Najla Al Ali","orcid":"0009-0002-1509-6319","position":5,"is_corresponding":false},{"id":1246223,"name":"Jeffrey A. Gilreath","orcid":"0000-0002-4566-8448","position":6,"is_corresponding":false},{"id":906289,"name":"Tibor Kovacsovics","orcid":"0000-0003-3294-0761","position":7,"is_corresponding":false},{"id":797880,"name":"Trang H. Au","orcid":"0000-0002-0149-0115","position":8,"is_corresponding":false},{"id":1098567,"name":"Malinda Tan","orcid":"0000-0002-0116-0538","position":9,"is_corresponding":false},{"id":1419181,"name":"Madeline Brendle","orcid":"0000-0003-0692-3706","position":10,"is_corresponding":false},{"id":284121,"name":"Rami S. Komrokji","orcid":"0000-0002-1876-5269","position":11,"is_corresponding":false},{"id":292238,"name":"Minkyoung Yoo","orcid":"0000-0002-9765-1197","position":12,"is_corresponding":false},{"id":1419642,"name":"Mushtaq Ashraf","orcid":null,"position":13,"is_corresponding":false},{"id":1419182,"name":"Aamir Khakwani","orcid":"0000-0001-9257-1836","position":14,"is_corresponding":false},{"id":1419643,"name":"Şerban R. Iorga","orcid":null,"position":15,"is_corresponding":false},{"id":1419183,"name":"Islam Sadek","orcid":"0000-0002-1072-4585","position":16,"is_corresponding":false},{"id":762311,"name":"David A. Sallman","orcid":"0000-0003-0504-8233","position":17,"is_corresponding":false},{"id":557272,"name":"David D. Stenehjem","orcid":"0000-0002-1831-285X","position":18,"is_corresponding":false},{"id":949106,"name":"Connor Willis","orcid":"0000-0001-7895-2747","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41283160","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}