{"doi":"10.1155/2024/6311938","title":"Identifying Who Benefits the Most from a Community Health Worker‐Led Multicomponent Intervention for Hypertension","abstract":"Background . Uncontrolled hypertension is a major public health challenge in low‐ and middle‐income countries. The Hypertension Control Program in Argentina (HCPIA) showed that a community health worker‐led multicomponent intervention was effective for blood pressure (BP) reduction in resource‐limited settings, but whether the intervention was equally effective across participant subgroups is unknown. Objective . To identify participants who benefit the most from the HCPIA BP control intervention. Methods . This secondary analysis used data from HCPIA, a successful 18‐month cluster‐randomized trial in 18 health centers with 1,432 low‐income hypertensive patients in Argentina. Fifteen baseline characteristics were used to define subgroups. The proportion of controlled BP (<140/90 mmHg) was estimated using generalized linear mixed models with arm‐by‐subgroup interaction terms. The distribution of trial BP response among intervention patient subgroups was assessed. Results . Participants were 53.0% female, a mean age of 56 years, and 17.4% controlled BP at baseline. After the intervention, 72.9% of intervention and 52.2% of control participants had controlled BP. The intervention was more effective in physically inactive patients (OR = 2.76, 95% CI: 1.82 and 4.21; p for interaction = 0.04), moderately active patients (OR = 3.08, 95% CI: 1.90 and 4.99; p for interaction = 0.03), and those with uncontrolled BP at baseline (OR = 2.77, 95% CI: 2.15 and 3.57; p for interaction = 0.05). Among intervention participants, 20.2% had no BP response (BP change < −4 mmHg), 41.3% had a moderate BP response (BP change: −4 mmHg to −24 mmHg), and 38.5% had a high BP response (BP change > −24 mmHg). Women ( p = 0.01), those who were physically inactive ( p = 0.03), and those not taking antihypertensive medications at baseline ( p = 0.001) had the greatest BP response. Conclusion . The effect of the intervention was consistent across many subgroups with some key groups showing a particularly strong intervention effect. These findings could be useful for planning future hypertension control programs in low‐ and middle‐income countries.","journal":"International Journal of Hypertension","year":2024,"id":503316,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":697939,"name":"Andrea Beratarrechea","orcid":"0000-0002-6397-4406","position":1,"is_corresponding":false},{"id":956779,"name":"Rosana Poggio","orcid":"0000-0002-3339-2421","position":2,"is_corresponding":false},{"id":379153,"name":"Hua He","orcid":"0000-0001-8989-0297","position":3,"is_corresponding":false},{"id":738683,"name":"Chung-Shiuan Chen","orcid":"0000-0001-8895-9651","position":4,"is_corresponding":false},{"id":261903,"name":"Jing Chen","orcid":"0000-0002-9035-9126","position":5,"is_corresponding":false},{"id":39461,"name":"Vilma Irazola","orcid":"0000-0002-6100-1862","position":6,"is_corresponding":false},{"id":1353226,"name":"Adolfo Rubinstein","orcid":"0000-0002-8418-6134","position":7,"is_corresponding":false},{"id":24759,"name":"Jiang He","orcid":"0000-0002-8286-9652","position":8,"is_corresponding":false},{"id":378209,"name":"Katherine T. Mills","orcid":"0000-0002-4278-5788","position":9,"is_corresponding":false},{"id":1353225,"name":"Meng Pan","orcid":"0000-0002-6734-0865","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:10:31.826282Z","pmid":"39319334","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}