{"doi":"10.1155/2023/4395556","title":"Predictive Value of 1-Hour Glucose Elevations during Oral Glucose Tolerance Testing for Cystic Fibrosis-Related Diabetes","abstract":"Background. In cystic fibrosis-related diabetes (CFRD) screening, oral glucose tolerance test (OGTT) thresholds for detecting prediabetes and diabetes are defined by the 2-hour glucose (2 hG). Intermediate OGTT glucoses, between 0 and 2 hours, that are ≥200 mg/dL are deemed “indeterminate,” although lower 1-hour glucose (1 hG) thresholds identify those at increased risk of type 2 diabetes in other populations, and may also better predict clinical decline in CF. Studies of 1 hG thresholds &lt;200 mg/dL in people with CF are limited. Methods. A single center, retrospective chart review was performed of patients with 1 hG available on OGTTs collected between 2010 and 2019. In patients with ≥2 OGTTs, Kaplan–Meier analysis estimated likelihood of progression to CFRD based on a high vs. low 1 hG. In patients with ≥1 OGTT, mixed-effects models tested whether baseline 1 hG and 2 hG predicted growth and lung function trajectories. Results. A total of 243 individuals with CF were identified with at least 1 OGTT including a 1 hG, and n = 177 had ≥2 OGTTs. Baseline age (mean ± SD) was 12.4 ± 2.6 years with 3.2 ± 1.4 years of follow-up. Twenty-eight developed CFRD. All who developed CFRD had a 1 hG ≥ 155 mg/dL prior to 2 hG &gt; 140 mg/dL. The average 1 hG was 267 mg/dL when 2 hG ≥ 200 mg/dL. In a subset with baseline 2 hG &lt; 140 mg/dL, 1 hG ≥ 140 mg/dL conferred an increased 5 years risk of CFRD ( <a:math xmlns:a=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"> <a:mi>p</a:mi> <a:mo>=</a:mo> <a:mn>0.036</a:mn> </a:math> ). Baseline 2 hG predicted decline in FEV1%predicted, but 1 hG did not. Conclusions. In youth with CF, 1 hG ≥ 140 mg/dl is an early indicator of CFRD risk. However, 2 hG, rather than 1 hG, predicted lung function decline.","journal":"Pediatric Diabetes","year":2023,"id":353764,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254435,"name":"Laura Pyle","orcid":"0000-0001-5577-8221","position":1,"is_corresponding":false},{"id":363948,"name":"Joon Ha","orcid":"0000-0003-4173-2534","position":2,"is_corresponding":false},{"id":363949,"name":"Arthur Sherman","orcid":"0000-0002-8372-5941","position":3,"is_corresponding":false},{"id":254440,"name":"Melanie Cree‐Green","orcid":"0000-0003-1593-1695","position":4,"is_corresponding":false},{"id":317016,"name":"Scott D. Sagel","orcid":"0000-0001-6172-4465","position":5,"is_corresponding":false},{"id":7391,"name":"Kristen J. Nadeau","orcid":"0000-0002-0477-3356","position":6,"is_corresponding":false},{"id":436470,"name":"Christine L. Chan","orcid":"0000-0003-3067-7672","position":7,"is_corresponding":false},{"id":1100438,"name":"Andrea Lorenz","orcid":"0000-0002-8044-3850","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:13:02.680107Z","pmid":"40303238","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}