{"doi":"10.1155/2022/5474397","title":"The Impact of Tobacco Use on COVID-19 Outcomes: A Systematic Review","abstract":"Introduction . Tobacco use increases risks for numerous diseases, including respiratory illnesses. We examined the literature to determine whether a history of tobacco use increases risks for adverse outcomes among COVID-19 patients. Methods . We conducted a systematic search of PubMed, LitCovid, Scopus, and Europe PMC (for preprints) using COVID-19 and tobacco-related terms. We included studies of human subjects with lab-confirmed COVID-19 infections that examined tobacco use history as an exposure and used multivariable analyses. The data was collected between March 31 st , 2020, and February 20 th , 2021. Outcomes included mortality, hospitalization, ICU admission, mechanical ventilation, and illness severity. Results . Among the 39 studies (33 peer-reviewed, 6 preprints) included, the most common outcome assessed was mortality ( n = 32). The majority of these studies (17/32) found that tobacco use increased risk, one found decreased risk, and 14 found no association. Tobacco use was associated with increased risk of hospitalization in 7 of 10 studies, ICU admission in 6 of 9 studies, mechanical ventilation in 2 of 6 studies, and illness severity in 3 of 9 studies. One study found that tobacco use history increased risk of pulmonary embolism in COVID-19 patients. Tobacco use was found to compound risks associated with diabetes ( n = 1), cancer ( n = 2), and chronic liver disease ( n = 1). Conclusion . There is strong evidence that tobacco use increases risks of mortality and disease severity/progression among COVID-19 patients. Public health efforts during the pandemic should encourage tobacco users to quit use and seek care early and promote vaccination and other preventive behaviors among those with a history of tobacco use.","journal":"The Journal of Smoking Cessation","year":2022,"id":246727,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8418,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":490192,"name":"Nandita Krishnan","orcid":"0000-0003-4957-2061","position":1,"is_corresponding":false},{"id":445544,"name":"Lorien C. Abroms","orcid":"0000-0001-6859-283X","position":2,"is_corresponding":false},{"id":356922,"name":"Carla J. Berg","orcid":"0000-0001-8931-1961","position":3,"is_corresponding":false},{"id":884024,"name":"Renée Bittoun","orcid":null,"position":4,"is_corresponding":false},{"id":883423,"name":"Jessica Baker","orcid":"0000-0003-2747-8728","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T00:23:48.622830Z","pmid":"35126740","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}