{"doi":"10.1155/2022/4474251","title":"Under- and Normal-Weight Patients Are More Susceptible to Recurrence of Phyllodes Tumor","abstract":"<jats:p>Purpose. Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms, and factors associated with the recurrence of PTs are poorly understood. This study sought to identify clinicopathological factors associated with the recurrence of PTs. Method. From January 2009 to December 2019, we identified 100 patients who underwent definitive surgery for PT. Clinicopathological risk factors associated with the recurrence of PT were assessed. Results. The median age of the patients was 44 y (range, 19–62 y), and the median tumor size was 4 cm (0.8–30 cm). At a median follow-up of 26.7 mo (0–103 mo), 22 of the 100 patients experienced local recurrence. In the univariate and multivariate analyses, body mass index ≥ 23 kg/m2 (<jats:inline-formula>\n                     <a:math xmlns:a=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\">\n                        <a:mi>P</a:mi>\n                     </a:math>\n                  </jats:inline-formula> = 0.042 in the univariate analysis; <jats:inline-formula>\n                     <c:math xmlns:c=\"http://www.w3.org/1998/Math/MathML\" id=\"M2\">\n                        <c:mi>P</c:mi>\n                     </c:math>\n                  </jats:inline-formula> = 0.039 in the multivariate analysis), tumor size ≥ 5 cm (<jats:inline-formula>\n                     <e:math xmlns:e=\"http://www.w3.org/1998/Math/MathML\" id=\"M3\">\n                        <e:mi>P</e:mi>\n                     </e:math>\n                  </jats:inline-formula> = 0.006 in the univariate analysis; <jats:inline-formula>\n                     <g:math xmlns:g=\"http://www.w3.org/1998/Math/MathML\" id=\"M4\">\n                        <g:mi>P</g:mi>\n                     </g:math>\n                  </jats:inline-formula> = 0.036 in the multivariate analysis), and the presence of stromal overgrowth (<jats:inline-formula>\n                     <i:math xmlns:i=\"http://www.w3.org/1998/Math/MathML\" id=\"M5\">\n                        <i:mi>P</i:mi>\n                     </i:math>\n                  </jats:inline-formula> = 0.032 in the univariate analysis; <jats:inline-formula>\n                     <k:math xmlns:k=\"http://www.w3.org/1998/Math/MathML\" id=\"M6\">\n                        <k:mi>P</k:mi>\n                     </k:math>\n                  </jats:inline-formula> = 0.040 in the multivariate analysis) were associated with an increased risk of local recurrence. Resection margins and grade were not associated with local recurrence. Conclusion. Normal- or underweight patients and those with larger tumor sizes were more prone to local recurrence. Further larger, multicenter studies with a long-term follow-up are required.</jats:p>","journal":"The Breast Journal","year":2022,"id":18580,"datarank":0.23021247647180432,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.06542063317158787,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.06542063317158787,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":128600,"name":"Hayeon Kim","orcid":"0000-0002-8869-3176","position":1,"is_corresponding":false},{"id":128601,"name":"Woo Young Kim","orcid":"0000-0001-6871-6855","position":2,"is_corresponding":false},{"id":128602,"name":"Jai Hyun Chung","orcid":"0000-0002-0889-5609","position":3,"is_corresponding":false},{"id":128603,"name":"Jae Bok Lee","orcid":"0000-0001-7977-3097","position":4,"is_corresponding":false},{"id":128604,"name":"Sang Uk Woo","orcid":"0000-0001-6218-4704","position":5,"is_corresponding":false},{"id":128599,"name":"Yong Yeup Kim","orcid":"0000-0003-3243-1852","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35711882","pmcid":"PMC9187276","openalex_id":"https://openalex.org/W4210903696","authors":[],"funders":[],"total_grants":0,"fwci":0.2919,"citation_percentile":0.52908371,"influential_citations":1,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.hindawi.com/journals/tbj/2022/4474251.pdf","host_type":"journal"},{"url":"https://downloads.hindawi.com/journals/tbj/2022/4474251.pdf","host_type":"GOLD"},{"url":"https://downloads.hindawi.com/journals/tbj/2022/4474251.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/tbj/2022/4474251.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/tbj/2022/4474251.xml","host_type":"publisher"},{"url":"http://doi.org/10.1155/2022/4474251","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35711882","host_type":"repository"},{"url":"https://doi.org/10.1155/2022/4474251","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9187276","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9187276","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9187276?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Breast Lesions and Carcinomas","Breast Cancer Treatment Studies","Cancer and Skin Lesions","Medicine","Breast","Breast Neoplasms","Female","Follow-Up Studies","Humans","Margins of Excision","Neoplasm Recurrence, Local","Phyllodes Tumor","Retrospective Studies"],"mesh_terms":["Margins of Excision","Breast","Breast Neoplasms","Phyllodes Tumor","Female","Follow-Up Studies","Humans","Neoplasm Recurrence, Local","Retrospective Studies"],"keywords":["Medicine","Multivariate analysis","Univariate analysis","Univariate","Underweight","Internal medicine","Body mass index","Gastroenterology","Multivariate statistics","Overweight"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-03T22:44:26.967486Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}