{"doi":"10.1155/2022/4450824","title":"Ibrutinib plus Obinutuzumab as Frontline Therapy for Chronic Lymphocytic Leukemia Is Associated with a Lower Rate of Infusion-Related Reactions and with Sustained Remissions after Ibrutinib Discontinuation: A Single-Arm, Open-Label, Phase 1b/2 Clinical Trial NCT0231576","abstract":"Ibrutinib-based therapies are costly and require continuous administration. We hypothesized combining BTK inhibition with anti-CD20 monoclonal antibodies would yield deep remissions allowing discontinuation. We enrolled 32 therapy-naïve CLL patients to receive ibrutinib plus obinutuzumab, followed by single-agent ibrutinib. Patients could discontinue ibrutinib after 36 months with sustained complete response (CR). We evaluated treatment safety, efficacy, and outcomes after ibrutinib discontinuation. The overall response rate was 100%, 28% achieved a CR, and 12.5% achieved bone marrow undetectable minimal residual disease. At a three-year median follow-up, 91% remain in remission with 100% overall survival. Five patients in sustained CR stopped ibrutinib and have not progressed. Eight non-CR patients discontinued for other reasons, with only two progressing. The treatment was safe, with a lower IRR rate. All patients responded to treatment with longer time-to-progression after discontinuation of ibrutinib. Our data support the evaluation of ibrutinib discontinuation strategies in more extensive clinical trials (https://Clinicaltrials.gov Identifier https://clinicaltrials.gov/ct2/show/NCT02315768).","journal":"Advances in Hematology","year":2022,"id":294208,"datarank":0.3076072421288781,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.09966308796089447,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.09966308796089447,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02315768"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353591,"name":"Paula A. Lengerke-Diaz","orcid":"0000-0002-1285-8499","position":1,"is_corresponding":false},{"id":979586,"name":"Juliana Vélez Luján","orcid":null,"position":2,"is_corresponding":false},{"id":273362,"name":"Michael Y. Choi","orcid":"0000-0002-9107-2186","position":3,"is_corresponding":false},{"id":829947,"name":"Eider Moreno-Cortes","orcid":"0000-0001-7629-6264","position":4,"is_corresponding":false},{"id":829948,"name":"José Vicente Forero-Forero","orcid":"0000-0001-9872-5760","position":5,"is_corresponding":false},{"id":829949,"name":"Juan Esteban García-Robledo","orcid":"0000-0003-2912-152X","position":6,"is_corresponding":false},{"id":829950,"name":"C Jacobs","orcid":"0000-0002-7294-4364","position":7,"is_corresponding":false},{"id":512579,"name":"Colin McCarthy","orcid":null,"position":8,"is_corresponding":false},{"id":830469,"name":"Alaina Heinen","orcid":null,"position":9,"is_corresponding":false},{"id":830470,"name":"Carlos I. Amaya-Chanaga","orcid":null,"position":10,"is_corresponding":false},{"id":242767,"name":"Thomas J. Kipps","orcid":"0000-0002-0064-4549","position":11,"is_corresponding":false},{"id":11118,"name":"Januario E. Castro","orcid":"0000-0003-2785-0892","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T00:30:57.469517Z","pmid":"35103064","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}