{"doi":"10.1155/2020/8877100","title":"Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes","abstract":"This study investigated the effect of anthracycline antibiotics, mitomycin C, and menadione on oxygen consumption and hydrogen peroxide production by intact, beating, rat heart myocytes. Doxorubicin produced a dose-dependent increase in the rate of cyanide-resistant respiration by beating myocytes. The anthracycline analogs 4-demethoxydaunorubicin, 4 <a:math xmlns:a=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><a:msup><a:mrow/><a:mrow><a:mo>′</a:mo></a:mrow></a:msup></a:math> -epidoxorubicin, 4 <c:math xmlns:c=\"http://www.w3.org/1998/Math/MathML\" id=\"M2\"><c:msup><c:mrow/><c:mrow><c:mo>′</c:mo></c:mrow></c:msup></c:math> -deoxydoxorubicin, and menogaril, as well as the anticancer quinones mitomycin C and menadione, also significantly increased oxygen consumption by cardiac myocytes. However, 5-iminodaunorubicin (which has a substituted quinone group) and mitoxantrone (which is not easily reduced by flavin dehydrogenases) had no effect on cardiac respiration. Both catalase (43%) and acetylated cytochrome c (19%) significantly decreased oxygen consumption that had been stimulated by doxorubicin; furthermore, extracellular hydrogen peroxide production was increased from undetectable control levels to <e:math xmlns:e=\"http://www.w3.org/1998/Math/MathML\" id=\"M3\"><e:mn>1.30</e:mn><e:mo>±</e:mo><e:mn>0.02</e:mn></e:math> nmol/min/107 myocytes ( <g:math xmlns:g=\"http://www.w3.org/1998/Math/MathML\" id=\"M4\"><g:mi>n</g:mi><g:mo>=</g:mo><g:mn>4</g:mn></g:math> , <i:math xmlns:i=\"http://www.w3.org/1998/Math/MathML\" id=\"M5\"><i:mi>P</i:mi><i:mo>&lt;</i:mo><i:mn>0.01</i:mn></i:math> ) in the presence of 400 μM doxorubicin. These experiments suggest that the anthracycline antibiotics and other anticancer quinones stimulate cardiac oxygen radical production in intact heart myocytes; such a free radical cascade could contribute to the cardiac toxicity of these drugs.","journal":"Oxidative Medicine and Cellular Longevity","year":2020,"id":83064,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":30164,"name":"James H. Doroshow","orcid":"0000-0002-4463-1790","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T21:54:09.383533Z","pmid":"33144915","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}