{"doi":"10.1155/2017/9372050","title":"Multiple Factors Involved in the Pathogenesis of White Matter Lesions","abstract":"<jats:p>White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.</jats:p>","journal":"BioMed Research International","year":2017,"id":604463,"datarank":5.135408330294189,"base_score":4.948759890378168,"endowment":4.948759890378168,"self_citation_contribution":0.7423139835567254,"citation_network_contribution":4.393094346737464,"self_endowment_contribution":0.7423139835567254,"citer_contribution":4.393094346737464,"corpus_percentile":null,"corpus_rank":null,"citation_count":140,"citer_count":140,"citers_with_citation_signal":109,"citers_with_endowment":109,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1550907,"name":"Dilong Wang","orcid":null,"position":1,"is_corresponding":false},{"id":1550908,"name":"Linfang Lan","orcid":null,"position":2,"is_corresponding":false},{"id":1550910,"name":"Yuhua Fan","orcid":"0000-0002-1172-1490","position":3,"is_corresponding":false},{"id":700437,"name":"Jing Lin","orcid":"0000-0002-6775-3125","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Multiple Factors Involved in the Pathogenesis of White Matter Lesions","abstract":"<jats:p>White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.</jats:p>","is_dataset_classified":null,"base_score":4.948759890378168,"endowment":4.948759890378168,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28316994","pmcid":"PMC5339523","openalex_id":"https://openalex.org/W2591216191","authors":[],"funders":[],"total_grants":0,"fwci":5.6294,"citation_percentile":0.96548606,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":10},{"year":2019,"count":15},{"year":2020,"count":15},{"year":2021,"count":16},{"year":2022,"count":26},{"year":2023,"count":13},{"year":2024,"count":16},{"year":2025,"count":19},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://downloads.hindawi.com/journals/bmri/2017/9372050.pdf","host_type":"journal"},{"url":"http://downloads.hindawi.com/journals/bmri/2017/9372050.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/bmri/2017/9372050.xml","host_type":"publisher"},{"url":"https://doi.org/10.1155/2017/9372050","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28316994","host_type":"repository"},{"url":"https://doaj.org/article/256b752aafb84420ae4883b5579b69fd","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5339523","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5339523","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5339523?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neurological Disease Mechanisms and Treatments","Cerebrovascular and genetic disorders","Acute Ischemic Stroke Management"],"mesh_terms":["Aged","Aging","Blood-Brain Barrier","Brain","Brain Ischemia","Cerebrovascular Circulation","Cognition Disorders","Collagen","Humans","Inflammation","Genetic Linkage","Magnetic Resonance Imaging","Middle Aged","Nervous System Diseases","Permeability","Vascular Diseases","Genetic Predisposition to Disease","Leukoencephalopathies","White Matter"],"keywords":["Hyperintensity","Leukoaraiosis","Pathogenesis","Medicine","Pathology","Dementia","White matter","Fluid-attenuated inversion recovery","Ischemia","CADASIL","Population","Cardiology","Neuroscience","Magnetic resonance imaging","Biology","Radiology","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:12:25.600933Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}