{"doi":"10.1155/2015/790203","title":"Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?","abstract":"<jats:p>Fibrosis is a debilitating condition that can lead to impairment of the affected organ’s function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues. Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor. Transforming growth factor-<jats:italic>β</jats:italic>(TGF-<jats:italic>β</jats:italic>) is one of the major profibrotic cytokines which promotes fibrosis by signaling abnormal ECM regulation. Hyaluronan (HA) is a major ECM glycosaminoglycan that is regulated by TGF-<jats:italic>β</jats:italic>and whose role in fibrosis is emerging. Aside from its role as a hydrating, space filling polymer, HA regulates different cellular functions and is known to have a role in wound healing and inflammation. Importantly, HA deposition is increased in multiple fibrotic diseases. In this review we highlight studies that link HA to fibrosis and discuss what is known about the role of HA, its receptors, and its anabolic and catabolic enzymes in different fibrotic diseases.</jats:p>","journal":"BioMed Research International","year":2015,"id":676481,"datarank":3.2629382629423103,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":2.5830483389693217,"self_endowment_contribution":0.6798899239729885,"citer_contribution":2.5830483389693217,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":90,"citers_with_citation_signal":81,"citers_with_endowment":81,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660185,"name":"Artin Soroosh","orcid":"0000-0002-1255-9333","position":1,"is_corresponding":false},{"id":483988,"name":"Carol A. de la Motte","orcid":null,"position":2,"is_corresponding":false},{"id":1767528,"name":"Sami Albeiroti","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?","abstract":"<jats:p>Fibrosis is a debilitating condition that can lead to impairment of the affected organ’s function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues. Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor. Transforming growth factor-<jats:italic>β</jats:italic>(TGF-<jats:italic>β</jats:italic>) is one of the major profibrotic cytokines which promotes fibrosis by signaling abnormal ECM regulation. Hyaluronan (HA) is a major ECM glycosaminoglycan that is regulated by TGF-<jats:italic>β</jats:italic>and whose role in fibrosis is emerging. Aside from its role as a hydrating, space filling polymer, HA regulates different cellular functions and is known to have a role in wound healing and inflammation. Importantly, HA deposition is increased in multiple fibrotic diseases. In this review we highlight studies that link HA to fibrosis and discuss what is known about the role of HA, its receptors, and its anabolic and catabolic enzymes in different fibrotic diseases.</jats:p>","is_dataset_classified":null,"base_score":4.532599493153256,"endowment":4.532599493153256,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26583132","pmcid":"PMC4637089","openalex_id":"https://openalex.org/W1853027491","authors":[],"funders":[{"funder_name":"National Heart, Lung, and Blood Institute","grant_id":"HL107147","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL107147","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK097948","title":null}],"total_grants":3,"fwci":3.6304,"citation_percentile":0.93182805,"influential_citations":0,"citation_trend":[{"year":2016,"count":6},{"year":2017,"count":8},{"year":2018,"count":11},{"year":2019,"count":9},{"year":2020,"count":9},{"year":2021,"count":5},{"year":2022,"count":10},{"year":2023,"count":8},{"year":2024,"count":10},{"year":2025,"count":12},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://downloads.hindawi.com/journals/bmri/2015/790203.pdf","host_type":"journal"},{"url":"http://downloads.hindawi.com/journals/bmri/2015/790203.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/bmri/2015/790203.xml","host_type":"publisher"},{"url":"https://doi.org/10.1155/2015/790203","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26583132","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637089","host_type":"repository"},{"url":"https://doaj.org/article/91b0e181f00a4f94962ab3eec6af1b2a","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4637089","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4637089?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Proteoglycans and glycosaminoglycans research","Connective tissue disorders research","Fibroblast Growth Factor Research","Actins","Collagen","Extracellular Matrix","Fibroblasts","Fibrosis","Humans","Hyaluronic Acid","Myofibroblasts","Signal Transduction","Transforming Growth Factor beta1"],"mesh_terms":["Actins","Collagen","Extracellular Matrix","Fibroblasts","Fibrosis","Humans","Hyaluronic Acid","Signal Transduction","Transforming Growth Factor beta1","Myofibroblasts"],"keywords":["Fibrosis","Extracellular matrix","Fibronectin","Transforming growth factor","Myofibroblast","Cell biology","Growth factor","CTGF","Wound healing","Inflammation","Connective tissue","Cancer research","Chemistry","Immunology","Biology","Medicine","Pathology","Receptor","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T02:38:56.590911Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}