{"doi":"10.1155/2015/506598","title":"Species Identification and Clarithromycin Susceptibility Testing of 278 Clinical Nontuberculosis Mycobacteria Isolates","abstract":"<jats:p>Purpose of this paper is to analyze different species’ proportion of nontuberculosis mycobacteria (NTM) and susceptibility to clarithromycin of different species. 278 clinical NTM isolates were identified into species by using 16S rRNA,<jats:italic>rpoB</jats:italic>and<jats:italic>hsp65</jats:italic>. Then clarithromycin susceptibility testing against different species was done separately, using microplate Alamar Blue assay. Finally, resistance isolates’<jats:italic>erm(41)</jats:italic>of<jats:italic>M. abscessus</jats:italic>were sequenced in order to analyze mechanisms for clarithromycin resistant. In this test, 131 isolates (47%) belonged to<jats:italic>M. avium</jats:italic>complex (MAC), and 70 isolates (25%) belonged to<jats:italic>M. abscessus</jats:italic>. Nearly all the<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>resistant to clarithromycin had T28 in<jats:italic>erm(41)</jats:italic>. However, all the<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>susceptible to clarithromycin had C28 in<jats:italic>erm(41)</jats:italic>. In this study, we find that MAC was the most common pathogens of NTM, and the second one was<jats:italic>M. abscessus</jats:italic>. However,<jats:italic>M. chelonei, M. fuerth</jats:italic>, and<jats:italic>M. gordon</jats:italic>were rare. Clarithromycin had a good inhibition activity against all the NTM species except<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>. The<jats:italic>erm(41)</jats:italic>genotype is of high relevance to clarithromycin resistance.</jats:p>","journal":"BioMed Research International","year":2015,"id":648215,"datarank":1.7356224786201684,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":1.2157620932002093,"self_endowment_contribution":0.519860385419959,"citer_contribution":1.2157620932002093,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":28,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1326637,"name":"Hongfei Duan","orcid":"0000-0002-8738-5737","position":1,"is_corresponding":false},{"id":1062002,"name":"Hairong Huang","orcid":"0009-0003-5363-5536","position":2,"is_corresponding":false},{"id":1283362,"name":"Yu Lu","orcid":"0000-0002-2516-4031","position":3,"is_corresponding":false},{"id":1689136,"name":"Naihui Chu","orcid":null,"position":4,"is_corresponding":false},{"id":1689130,"name":"Wenjuan Nie","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Species Identification and Clarithromycin Susceptibility Testing of 278 Clinical Nontuberculosis Mycobacteria Isolates","abstract":"<jats:p>Purpose of this paper is to analyze different species’ proportion of nontuberculosis mycobacteria (NTM) and susceptibility to clarithromycin of different species. 278 clinical NTM isolates were identified into species by using 16S rRNA,<jats:italic>rpoB</jats:italic>and<jats:italic>hsp65</jats:italic>. Then clarithromycin susceptibility testing against different species was done separately, using microplate Alamar Blue assay. Finally, resistance isolates’<jats:italic>erm(41)</jats:italic>of<jats:italic>M. abscessus</jats:italic>were sequenced in order to analyze mechanisms for clarithromycin resistant. In this test, 131 isolates (47%) belonged to<jats:italic>M. avium</jats:italic>complex (MAC), and 70 isolates (25%) belonged to<jats:italic>M. abscessus</jats:italic>. Nearly all the<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>resistant to clarithromycin had T28 in<jats:italic>erm(41)</jats:italic>. However, all the<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>susceptible to clarithromycin had C28 in<jats:italic>erm(41)</jats:italic>. In this study, we find that MAC was the most common pathogens of NTM, and the second one was<jats:italic>M. abscessus</jats:italic>. However,<jats:italic>M. chelonei, M. fuerth</jats:italic>, and<jats:italic>M. gordon</jats:italic>were rare. Clarithromycin had a good inhibition activity against all the NTM species except<jats:italic>M. abscessus</jats:italic>subsp.<jats:italic>abscessus</jats:italic>. The<jats:italic>erm(41)</jats:italic>genotype is of high relevance to clarithromycin resistance.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26146620","pmcid":"PMC4469756","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://downloads.hindawi.com/journals/bmri/2015/506598.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/bmri/2015/506598.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/bmri/2015/506598.xml","host_type":"publisher"},{"url":"https://doaj.org/article/f93e475b0fcb4d7ab9d22bd87dab233d","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469756","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4469756","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4469756?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Clarithromycin","RNA, Ribosomal, 16S","Anti-Bacterial Agents","Microbial Sensitivity Tests","Genotype","Mycobacterium Infections, Nontuberculous","Nontuberculous Mycobacteria"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:22:33.821546Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}