{"doi":"10.1155/2013/589139","title":"Evidence for Bone Marrow Adult Stem Cell Plasticity: Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation","abstract":"<jats:p>In contrast to the pluripotent<jats:italic>embryonic stem cells</jats:italic>(ESCs) which are able to give rise to all cell types of the body, mammalian<jats:italic>adult stem cells</jats:italic>(ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted central dogmas of commitment of ASCs by showing their plasticity to differentiate across tissue lineage boundaries, irrespective of classical germ layer designations. The present paper supports the plasticity of the<jats:italic>bone marrow stem cells</jats:italic>(BMSCs), bringing the most striking and the latest evidences of the transdifferentiation properties of the<jats:italic>bone marrow hematopoietic and mesenchymal stem cells</jats:italic>(BMHSCs, and BMMSCs), the two BM populations of ASCs better characterized. In addition, we report the possible mechanisms that may explain these events, outlining the clinical importance of these phenomena and the relative problems.</jats:p>","journal":"Stem Cells International","year":2013,"id":40502,"datarank":2.2276314898477665,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":1.6378576449391176,"self_endowment_contribution":0.5897738449086489,"citer_contribution":1.6378576449391176,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":50,"citers_with_citation_signal":45,"citers_with_endowment":45,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196704,"name":"Simona Berardi","orcid":null,"position":1,"is_corresponding":false},{"id":196705,"name":"Antonia Reale","orcid":null,"position":2,"is_corresponding":false},{"id":196706,"name":"Annunziata De Luisi","orcid":null,"position":3,"is_corresponding":false},{"id":196707,"name":"Vito Racanelli","orcid":null,"position":4,"is_corresponding":false},{"id":187416,"name":"Angelo Vacca","orcid":null,"position":5,"is_corresponding":false},{"id":196708,"name":"Roberto Ria","orcid":null,"position":6,"is_corresponding":false},{"id":196703,"name":"Ivana Catacchio","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23606860","pmcid":"PMC3625599","openalex_id":"https://openalex.org/W2050290800","authors":[],"funders":[{"funder_name":"Associazione Italiana per la Ricerca sul Cancro","grant_id":"9965","title":null},{"funder_name":"Associazione Italiana per la Ricerca sul Cancro","grant_id":"278706","title":"Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance"},{"funder_name":"Ministero dell'Istruzione dell'Università e della Ricerca","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":2.9677,"citation_percentile":0.91220416,"influential_citations":4,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":7},{"year":2015,"count":7},{"year":2016,"count":4},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":6},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.hindawi.com/journals/sci/2013/589139.pdf","host_type":"journal"},{"url":"https://downloads.hindawi.com/journals/sci/2013/589139.pdf","host_type":"GOLD"},{"url":"https://downloads.hindawi.com/journals/sci/2013/589139.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/sci/2013/589139.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/sci/2013/589139.xml","host_type":"publisher"},{"url":"https://doi.org/10.1155/2013/589139","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23606860","host_type":"repository"},{"url":"https://doaj.org/article/5a14b7dd659c462086eb315b26ad7cf9","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3625599","host_type":"repository"},{"url":"https://hdl.handle.net/11572/387679","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3625599","host_type":"repository"},{"url":"http://hdl.handle.net/11586/223584","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3625599","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3625599?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1155/2013/589139","host_type":""},{"url":"https://dx.doi.org/10.1155/2013/589139","host_type":""},{"url":"https://doi.org/https://doi.org/10.1155/2013/589139","host_type":""}],"fields_of_study":["Mesenchymal stem cell research","Pluripotent Stem Cells Research","Hematopoietic Stem Cell Transplantation","Medicine","Biology","0301 basic medicine","03 medical and health sciences"],"mesh_terms":[],"keywords":["Transdifferentiation","Stem cell","Clinical uses of mesenchymal stem cells","Mesenchymal stem cell","Biology","Adult stem cell","Bone marrow","Stem cell transplantation for articular cartilage repair","Embryonic stem cell","Haematopoiesis","Induced pluripotent stem cell","Cell biology","Germ layer","Pathology","Immunology","Medicine","Genetics","Gene","Cell Biology; 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