{"doi":"10.1155/2013/483286","title":"Chemical and Biological Assessment of<i>Angelica</i>Roots from Different Cultivated Regions in a Chinese Herbal Decoction Danggui Buxue Tang","abstract":"<jats:p>Roots of<jats:italic>Angelica sinensis</jats:italic>(Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of<jats:italic>Angelica</jats:italic>roots called<jats:italic>A. gigas</jats:italic>is being used in Korea. To reveal the efficiency of different<jats:italic>Angelica</jats:italic>roots, the chemical and biological properties of<jats:italic>Angelica</jats:italic>roots from different cultivated regions were compared. Roots of<jats:italic>A. sinensis</jats:italic>contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in<jats:italic>A. gigas</jats:italic>roots. The extracts deriving from<jats:italic>A. gigas</jats:italic>roots showed better effects in osteogenic and estrogenic properties than that of<jats:italic>A. sinensis</jats:italic>from China. However, this difference was markedly reduced when the<jats:italic>Angelica</jats:italic>roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from<jats:italic>A. sinensis</jats:italic>roots showed better responses in cell cultures. In addition, the extracts of<jats:italic>A. gigas</jats:italic>roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of<jats:italic>Angelica</jats:italic>roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction.</jats:p>","journal":"Evidence-Based Complementary and Alternative Medicine","year":2013,"id":41911,"datarank":1.452659025087997,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.9959806594294834,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.9959806594294834,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":19,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201275,"name":"Ken Y. 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