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An improved method has been developed for the<jats:italic>in vitro</jats:italic>production of<jats:italic>P. falciparum</jats:italic>gametocytes as the first step toward obtaining adequate numbers of pure gametocytes for<jats:italic>in vitro</jats:italic>studies, such as, for example, the identification of transmission blocking drugs.</jats:p>","journal":"Journal of Parasitology Research","year":2012,"id":600308,"datarank":0.6307038929086449,"base_score":4.204692619390966,"endowment":4.204692619390966,"self_citation_contribution":0.6307038929086449,"citation_network_contribution":0.0,"self_endowment_contribution":0.6307038929086449,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1538981,"name":"Jaume Vidal-Mas","orcid":null,"position":1,"is_corresponding":false},{"id":632938,"name":"Didier Leroy","orcid":"0000-0002-5594-3204","position":2,"is_corresponding":false},{"id":1538982,"name":"Esperanza Herreros","orcid":null,"position":3,"is_corresponding":false},{"id":1538980,"name":"María Roncalés","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison and Optimization of Different Methods for the<i>In Vitro</i>Production of<i>Plasmodium falciparum</i>Gametocytes","abstract":"<jats:p>The generation of sexually committed parasites (gametocytogenesis) is poorly understood in malaria. If the mechanisms regulating this process were elucidated, new opportunities for blocking malaria transmission could be revealed. Here we compare several methods described previously for the<jats:italic>in vitro</jats:italic>production of<jats:italic>Plasmodium falciparum</jats:italic>gametocytes. Our approach relies on the combination of several factors that we demonstrated as impacting on or being critical to gametocytogenesis. 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