{"doi":"10.1155/2012/345195","title":"Structure-Function of Falcipains: Malarial Cysteine Proteases","abstract":"<jats:p>Evidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemoglobin hydrolysis. The best characterized<jats:italic>Plasmodium</jats:italic>cysteine proteases are falcipains, which are papain family enzymes. Falcipain-2 and falcipain-3 are major hemoglobinases of<jats:italic>P. falciparum</jats:italic>. Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain. Overall, the complexes of falcipain-2 and falcipain-3 with small and macromolecular inhibitors provide structural insight to facilitate the design or modification of effective drug treatment against malaria. Drug development targeting falcipains should be aided by a strong foundation of biochemical and structural studies.</jats:p>","journal":"Journal of Tropical Medicine","year":2012,"id":25388,"datarank":1.8297933137276083,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":1.2286933359427377,"self_endowment_contribution":0.6010999777848708,"citer_contribution":1.2286933359427377,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":45,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":149483,"name":"Rajnikant Dixit","orcid":null,"position":1,"is_corresponding":false},{"id":149482,"name":"Kailash C. 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