{"doi":"10.1155/2010/893893","title":"Liver Transplantation for Hepatitis C and Alcoholic Liver Disease","abstract":"<jats:p>End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of significant alcohol intake prior to transplantation. However, there are few data available about the possible interaction between alcohol and HCV in the post-transplant setting. Patients with both HCV and alcohol are more likely to die on the waiting list than those with ALD and HCV alone. However, after transplantation, non-risk adjusted graft and patient survival of patients with HCV + ALD are comparable to those of patients with HCV cirrhosis or ALD cirrhosis alone. In the short and medium term HCV recurrence after transplant in patients with HCV + ALD cirrhosis does not seem more aggressive than that in patients with HCV cirrhosis alone. A relapse in alcohol consumption in patients with HCV + ALD cirrhosis does not have a major impact on graft survival. The evidence shows that, as is currently practiced, HCV + ALD as an appropriate indication for liver transplantation. However, these data are based on retrospective analyses with relatively short follow-up so the conclusions must be treated with caution.</jats:p>","journal":"Journal of Transplantation","year":2010,"id":687857,"datarank":0.6328875551983599,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.32097132394638456,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.32097132394638456,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":97507,"name":"James Neuberger","orcid":"0000-0002-6079-002X","position":1,"is_corresponding":false},{"id":97371,"name":"Marco Carbone","orcid":"0000-0003-1445-0443","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Liver Transplantation for Hepatitis C and Alcoholic Liver Disease","abstract":"<jats:p>End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of significant alcohol intake prior to transplantation. However, there are few data available about the possible interaction between alcohol and HCV in the post-transplant setting. Patients with both HCV and alcohol are more likely to die on the waiting list than those with ALD and HCV alone. However, after transplantation, non-risk adjusted graft and patient survival of patients with HCV + ALD are comparable to those of patients with HCV cirrhosis or ALD cirrhosis alone. In the short and medium term HCV recurrence after transplant in patients with HCV + ALD cirrhosis does not seem more aggressive than that in patients with HCV cirrhosis alone. A relapse in alcohol consumption in patients with HCV + ALD cirrhosis does not have a major impact on graft survival. The evidence shows that, as is currently practiced, HCV + ALD as an appropriate indication for liver transplantation. However, these data are based on retrospective analyses with relatively short follow-up so the conclusions must be treated with caution.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21209701","pmcid":"PMC3010646","openalex_id":"https://openalex.org/W2077962329","authors":[],"funders":[],"total_grants":0,"fwci":0.2759,"citation_percentile":0.57874531,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2019,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.hindawi.com/journals/jtrans/2010/893893.pdf","host_type":"journal"},{"url":"https://downloads.hindawi.com/journals/jtrans/2010/893893.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/jtrans/2010/893893.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/jtrans/2010/893893.xml","host_type":"publisher"},{"url":"https://doi.org/10.1155/2010/893893","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21209701","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3010646","host_type":"repository"},{"url":"https://doaj.org/article/71508d3ad47142fb95e4282e8153506a","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3010646","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3010646?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Hepatitis C virus research","Liver Disease and Transplantation","Liver Disease Diagnosis and Treatment"],"mesh_terms":[],"keywords":["Medicine","Cirrhosis","Alcoholic liver disease","Liver transplantation","Hepatitis C","Transplantation","Liver disease","Alcoholic hepatitis","Internal medicine","Gastroenterology","Alcohol","Hepatitis C virus","Immunology","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T02:10:41.466713Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}