{"doi":"10.1155/2010/164586","title":"Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma","abstract":"<jats:p><jats:italic>Background</jats:italic>. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors.<jats:italic>Objective</jats:italic>. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL).<jats:italic>Methods</jats:italic>. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines.<jats:italic>Results</jats:italic>. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13.<jats:italic>Conclusions</jats:italic>. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.</jats:p>","journal":"AIDS Research and Treatment","year":2010,"id":625998,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":890749,"name":"Dorina Gui","orcid":"0000-0002-1500-6689","position":1,"is_corresponding":false},{"id":1184527,"name":"Laura M. Popoviciu","orcid":null,"position":2,"is_corresponding":false},{"id":928676,"name":"Jonathan W. Said","orcid":"0000-0002-0876-0632","position":3,"is_corresponding":false},{"id":337739,"name":"Elizabeth C. Breen","orcid":"0000-0001-6046-4999","position":4,"is_corresponding":false},{"id":810066,"name":"Xin Huang","orcid":"0000-0002-0359-7290","position":5,"is_corresponding":false},{"id":1619213,"name":"Christina M. R. Kitchen","orcid":null,"position":6,"is_corresponding":false},{"id":1619214,"name":"Juan M. Alcantar","orcid":null,"position":7,"is_corresponding":false},{"id":1619215,"name":"Jeffrey B. Smith","orcid":null,"position":8,"is_corresponding":false},{"id":518093,"name":"Roger Detels","orcid":"0000-0002-6622-9655","position":9,"is_corresponding":false},{"id":1619216,"name":"Otoniel Martínez-Maza","orcid":null,"position":10,"is_corresponding":false},{"id":1619212,"name":"Daniel P. Widney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma","abstract":"<jats:p><jats:italic>Background</jats:italic>. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors.<jats:italic>Objective</jats:italic>. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL).<jats:italic>Methods</jats:italic>. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines.<jats:italic>Results</jats:italic>. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13.<jats:italic>Conclusions</jats:italic>. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.</jats:p>","is_dataset_classified":null,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21490903","pmcid":"PMC3065842","openalex_id":"https://openalex.org/W2167649628","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"CA57152","title":null},{"funder_name":"National Institutes of Health","grant_id":"CA73475","title":null},{"funder_name":"National Institutes of Health","grant_id":"AI28697","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-35042","title":null},{"funder_name":"National Institutes of Health","grant_id":"5-MO1-RR-00722","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-35043","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-37984","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-35039","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-35040","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-37613","title":null},{"funder_name":"National Institutes of Health","grant_id":"UO1-AI-35041","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA073475","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035042","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI037984","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA057152","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA016042","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035039","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI037613","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR000722","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035043","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P30 AI028697","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035040","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U01 AI035041","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035043-18","title":"Center/Coordination, Analysis and Management/MACS"},{"funder_name":"National Institutes of Health","grant_id":"5P30AI028697-26","title":"Biostatistics Core"},{"funder_name":"National Institutes of Health","grant_id":"3U01AI035040-01S1","title":"NATURAL HISTORY OF AIDS IN HOMOSEXUAL MEN"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035042-21","title":"Multicenter AIDS Cohort Study - Part B (Baltimore Center)"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI035039-15","title":"MULTICENTER AIDS COHORT STUDY"},{"funder_name":"National Institutes of Health","grant_id":"5R01CA073475-06","title":"Molecular Epidemiology of AIDS-Associated Lymphoma"},{"funder_name":"National Institutes of Health","grant_id":"5U01AI037613-07","title":"MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH LABS"},{"funder_name":"National Institutes of Health","grant_id":"3P30CA016042-35S3","title":"Cancer Center Support Grant"},{"funder_name":"National Institutes of Health","grant_id":"3U01AI037984-03S1","title":"MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH"},{"funder_name":"National Institutes of Health","grant_id":"5R01CA057152-06","title":"IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA"}],"total_grants":33,"fwci":1.2333,"citation_percentile":0.7946284,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.hindawi.com/journals/art/2010/164586.pdf","host_type":"journal"},{"url":"https://downloads.hindawi.com/journals/art/2010/164586.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/art/2010/164586.pdf","host_type":"publisher"},{"url":"http://downloads.hindawi.com/journals/art/2010/164586.xml","host_type":"publisher"},{"url":"https://doi.org/10.1155/2010/164586","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21490903","host_type":"repository"},{"url":"https://doaj.org/article/13419c98495d4592a506b923326f875e","host_type":"repository"},{"url":"https://escholarship.org/uc/item/1ck405n3","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3065842","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3065842","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3065842?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1155/2010/164586","host_type":""},{"url":"https://dx.doi.org/10.1155/2010/164586","host_type":""},{"url":"https://escholarship.org/content/qt1ck405n3/qt1ck405n3.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1155/2010/164586","host_type":""}],"fields_of_study":["Chemokine receptors and signaling","Immunotherapy and Immune Responses","Immune Cell Function and Interaction","0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["CXCR5","CXCL13","Medicine","Chemokine receptor","CCL21","Hodgkin lymphoma","Lymphoma","Chemokine","C-C chemokine receptor type 7","CC chemokine receptors","Function (biology)","Cancer research","Receptor","Immunology","Internal medicine","Biology","Cell biology","Lymphatic Research","Public health","Biomedical and Clinical Sciences","Oncology and Carcinogenesis","Clinical Sciences","610","Hematology","RC581-607","Rare Diseases","Infectious Diseases","Clinical Research","HIV/AIDS","Sexually Transmitted Infections","Immunologic diseases. 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