{"doi":"10.1152/physiolgenomics.00212.2025","title":"Chamber-specific transcriptomic insight into cardiac development using guinea pig and human heart tissue","abstract":"Existing knowledge on postnatal heart development and cardiomyocyte maturation is limited. We investigated age-dependent transcriptional changes in neonatal, juvenile, and adult guinea pig hearts and then conducted a cross-species comparison to identify age-specific patterns that are conserved in the guinea pig and human atria. Expanding our knowledge of chamber- and age-specific gene expression patterns can inform and guide the selection of cardiovascular therapies in the pediatric population, where developmental differences are understudied.","journal":"Physiological Genomics","year":2025,"id":580260,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9295,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":558718,"name":"Devon Guerrelli","orcid":"0000-0003-0025-5997","position":1,"is_corresponding":false},{"id":671893,"name":"Luther Swift","orcid":"0000-0002-0050-1329","position":2,"is_corresponding":false},{"id":1478820,"name":"Anika Haski","orcid":null,"position":3,"is_corresponding":false},{"id":1262655,"name":"Alisa Bruce","orcid":null,"position":4,"is_corresponding":false},{"id":979805,"name":"Manan Desai","orcid":"0000-0002-5114-8641","position":5,"is_corresponding":false},{"id":322795,"name":"Yves d’Udekem","orcid":"0000-0003-1851-7836","position":6,"is_corresponding":false},{"id":283026,"name":"Nikki Gillum Posnack","orcid":"0000-0002-3880-7200","position":7,"is_corresponding":false},{"id":1056000,"name":"Shatha Salameh","orcid":"0000-0001-9624-4277","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:58:38.868285Z","pmid":"41196187","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}