{"doi":"10.1152/physiolgenomics.00156.2024","title":"Localization and quantification of placental <i>HDAC9</i> and <i>RGS2</i> during preeclampsia","abstract":"Syncytiotrophoblast stress contributes to the pathogenesis of preeclampsia, but many of the underlying causes remain undetermined. Previous work has implicated the loss of placental HDAC9-mediated Rgs2 transcription in the disorder. Extending these findings, we report that HDAC9 and RGS2 were abundant and localized primarily to syncytiotrophoblast cells of the control placenta. Expression of both targets was attenuated in these cells during preeclampsia and thus may be an underappreciated source of syncytiotrophoblast stress, warranting further investigation.","journal":"Physiological Genomics","year":2025,"id":575632,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1085348,"name":"Mary Christine Livergood","orcid":null,"position":1,"is_corresponding":false},{"id":370963,"name":"Kirthikaa Balapattabi","orcid":"0000-0001-5455-6037","position":2,"is_corresponding":false},{"id":978049,"name":"McKenzie L. Ritter","orcid":"0000-0001-9560-1316","position":3,"is_corresponding":false},{"id":446759,"name":"Curt D. Sigmund","orcid":"0000-0002-1453-0921","position":4,"is_corresponding":false},{"id":103857,"name":"Anne E. Kwitek","orcid":"0000-0003-1024-4116","position":5,"is_corresponding":false},{"id":370966,"name":"Justin L. Grobe","orcid":"0000-0001-9737-0873","position":6,"is_corresponding":false},{"id":323868,"name":"Jennifer McIntosh","orcid":"0000-0002-0299-9589","position":7,"is_corresponding":false},{"id":978050,"name":"Megan Opichka","orcid":"0000-0002-2961-8977","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:57:52.712371Z","pmid":"40983484","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}