{"doi":"10.1152/physiolgenomics.00058.2023","title":"High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their children","abstract":"Preeclampsia is a life-threatening hypertensive disorder, affecting 2%-5% of pregnancies, that remains poorly understood. This study analyzed DNA methylation from buccal swabs from mothers who experienced early and late-stage preeclampsia and those with uncomplicated pregnancies, along with their children. Differentially methylated regions were found near and within genes crucial for placental function, embryonic development, and inflammation. Many of these genes are expressed in preeclampsia-related tissues, offering hope for future biomarker development for this condition.","journal":"Physiological Genomics","year":2024,"id":446267,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":645964,"name":"Samantha Ward","orcid":"0000-0002-5857-1071","position":1,"is_corresponding":false},{"id":307550,"name":"Brett A. Davis","orcid":"0000-0001-7985-1921","position":2,"is_corresponding":false},{"id":408793,"name":"Kimberly A. Nevonen","orcid":"0000-0003-0198-1624","position":3,"is_corresponding":false},{"id":172773,"name":"Mariam Okhovat","orcid":"0000-0002-3145-9397","position":4,"is_corresponding":false},{"id":426754,"name":"Mónica Rincón","orcid":"0000-0001-5574-585X","position":5,"is_corresponding":false},{"id":658183,"name":"Amy M. Valent","orcid":"0000-0003-3832-2024","position":6,"is_corresponding":false},{"id":51330,"name":"Lucia Carbone","orcid":"0000-0002-2118-107X","position":7,"is_corresponding":false},{"id":410975,"name":"Kent L. Thornburg","orcid":"0000-0002-5561-4785","position":8,"is_corresponding":false},{"id":985041,"name":"Cora E. Layman","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:50.465308Z","pmid":"38189116","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}