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This recruitment process is thought to be rate-limiting, requiring tens of seconds. In contrast, a form of endocytosis in neurons called ultrafast endocytosis is much faster, requiring only 100 ms. In this review, we compare the mechanisms of protein recruitment during clathrin-mediated endocytosis in nonneuronal cells and ultrafast endocytosis in neurons and discuss how endocytosis can complete within 100 ms. 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