{"doi":"10.1152/physiol.00005.2013","title":"In Scarcity and Abundance: Metabolic Signals Regulating Cell Growth","abstract":"<jats:p>Although nutrient availability is a major driver of cell growth, and continuous adaptation to nutrient supply is critical for the development and survival of all organisms, the molecular mechanisms of nutrient sensing are only beginning to emerge. Here, we highlight recent advances in the field of nutrient sensing and discuss arising principles governing how metabolism might regulate growth-promoting pathways. In addition, we discuss signaling functions of metabolic enzymes not directly related to their metabolic activity.</jats:p>","journal":"Physiology","year":2013,"id":678863,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145729,"name":"Matthias Peter","orcid":null,"position":1,"is_corresponding":false},{"id":1773714,"name":"Reinhard Dechant","orcid":null,"position":2,"is_corresponding":false},{"id":750760,"name":"Shady Saad","orcid":"0000-0003-1062-2906","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In Scarcity and Abundance: Metabolic Signals Regulating Cell Growth","abstract":"<jats:p>Although nutrient availability is a major driver of cell growth, and continuous adaptation to nutrient supply is critical for the development and survival of all organisms, the molecular mechanisms of nutrient sensing are only beginning to emerge. Here, we highlight recent advances in the field of nutrient sensing and discuss arising principles governing how metabolism might regulate growth-promoting pathways. In addition, we discuss signaling functions of metabolic enzymes not directly related to their metabolic activity.</jats:p>","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23997189","pmcid":"PMC3768095","openalex_id":"https://openalex.org/W2083552703","authors":[],"funders":[{"funder_name":"Swiss National Science Foundation","grant_id":"137160","title":"Mechanisms of metabolic stress signaling in cancer"},{"funder_name":"European Commission","grant_id":"268930","title":"Regulation of cell growth and division by selective degradation mechanisms"},{"funder_name":"Swiss National Science Foundation","grant_id":"141148","title":"Function and regulation of cullin-based E3 ubiquitin-ligases"},{"funder_name":"Swiss National Science Foundation","grant_id":"137143","title":"The Metabolic Basis of Disease"}],"total_grants":4,"fwci":0.605,"citation_percentile":0.6906415,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":4},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.physiology.org/doi/pdf/10.1152/physiol.00005.2013","host_type":"publisher"},{"url":"https://doi.org/10.1152/physiol.00005.2013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23997189","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3768095","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3768095","host_type":""},{"url":"http://dx.doi.org/10.1152/physiol.00005.2013","host_type":""},{"url":"https://dx.doi.org/10.1152/physiol.00005.2013","host_type":""},{"url":"https://sonar.ch/global/documents/238793","host_type":""}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Metabolism, Diabetes, and Cancer","Pancreatic function and diabetes","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adaptation, Physiological","Animals","Cell Enlargement","Cell Proliferation","Cell Survival","Energy Metabolism","Evolution, Molecular","Humans","Signal Transduction"],"mesh_terms":["Adaptation, Physiological","Animals","Cell Survival","Energy Metabolism","Humans","Signal Transduction","Evolution, Molecular","Cell Enlargement","Cell Proliferation"],"keywords":["Nutrient sensing","Biology","Nutrient","Cell metabolism","Metabolic pathway","Metabolism","Adaptation (eye)","Cell biology","Signal transduction","Metabolic regulation","Ecology","Biochemistry","Neuroscience","Evolution, Molecular","Cell Survival","Animals","Humans","Cell Enlargement","Energy Metabolism","Adaptation, Physiological","Cell Proliferation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T11:39:33.135688Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}